GHS Classification Result

Chemical Name:2-chloro-2',6'-diethyl-N-(methoxymethyl)acetanilide
CAS:15972-60-8

Result:
ID: 380
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as flammable according to ICSC (2006).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures, since the substance is stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
11 Self-heating substances and mixtures Not classified - - - - Stable to heat (up to 150degC) (Agricultural Chemical Registration Data)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine and oxygen (but not fluorine), with the chlorine and oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data on the substances with melting points of <55degC (melting point: 40.5-41.5degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 1,150mg/kg (Agricultural Chemical Registration Data (1998)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rabbit LD50 (dermal route) value of 13,300mg/kg (Agricultural Chemical Registration Data (1998)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >1.040mg/L, together with the absence of mortality (Agricultural Chemical Registration Data (1998)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the evidence of mild irritation with a Draize score of 2.0, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (2000)).
3 Serious eye damage/eye irritation Not classified - - - - Based on test data from rabbit eye irritation studies (Agricultural Chemical Registration Data (1998)): "Non-irritating to the eye."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on positive results in guinea pig skin sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1999)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vivo micronucleus tests on rat and mouse bone marrow cells and in vivo chromosome aberration tests on rat bone marrow cells, though in vitro chromosome aberration tests showed positive (Agricultural Chemical Registration Data (1998, 2002)).
6 Carcinogenicity Classification not possible - - - - Based on a judgment made by experts in the absence of existing classification, though the available data on carcinogenicity studies in rats and mice provide some evidence of non-genotoxic rat-specific tumor incidence.
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction or offspring development observed in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1980, 1981, 1988)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - No symptoms or signs referable to specific target organs were observed in the available animal studies (Agricultural Chemical Registration Data (1998)).
9 Specific target organ toxicity - Repeated exposure Category 2 (liver) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including an increase in liver weights/liver-to-body weight ratio, fatty degeneration of the liver, and bile duct hyperplasia (Agricultural Chemical Registration Data (1998)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 72 hours EbC50=0.0115mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 1989).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=3.52(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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