GHS Classification Result

Chemical Name:1-Chloro-2,4-dinitrobenzene
CAS:97-00-7

Result:
ID: 381
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Cannot be classified due to lack of data on decomposition energy, though the substance contains nitro groups, with its oxygen budget calculated at -75 and the kick-off temperature of 250degC (Bretherick (J), 5th, 1998). Classified into Division 6.1 in accordance with the classification by the UN Recommendations on the Transport of Dangerous Goods (UN#0154, chlorodinitrobenzene (solid)).
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Cannot be classified due to lack of data, though classified as "combustible" by ICSC (2000). Classified into Division 6.1, in accordance with the classification by the UN Recommendations on the Transport of Dangerous Goods (UN#3441, chlorodinitrobenzene (solid)).
8 Self-reactive substances and mixtures Not classified - - - - No data available, though containing nitro groups. Classified into Division 6.1, in accordance with the classification by the UN Recommendations on the Transport of Dangerous Goods (UN#3441, chlorodinitrobenzene (solid)).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 432degC (ICSC, 2000)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 54degC (ICSC, 2000), test temperature: 140degC)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - Organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1, in accordance with the classification by the UN Recommendations on the Transport of Dangerous Goods (UN#3441, chlorodinitrobenzene (solid)).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1, in accordance with the classification by the UN Recommendations on the Transport of Dangerous Goods (UN#3441, chlorodinitrobenzene (solid)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 640mg/kg (MOE Risk Assessment vol.3 (2004)).
1 Acute toxicity (Dermal) Category 2 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rabbit LD50 (dermal route) value of 130mg/kg (CERI Hazard Data 2000-41 (2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 2000-41 (2001)): The substance produced "severe skin irritation." Although it is unknown whether the effects are reversible or not, the substance is placed in Category 2, given the fact that the results are those of 24- (not 4) hour application.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
Based on the evidence of "severe irritation" in the rabbit eye irritation tests (CERI Hazard Data 2000-41 (2001)). As it is unknown whether the effects are reversible or not, the substance is placed in Category 1 from the viewpoint of safety.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the description in the report on the animal skin sensitization tests (CERI Hazard Data 2000-41 (2001)): "The substance causes skin sensitization." Also based on the evidence of skin sensitization in humans (CERI Hazard Data 2000-41 (2001)).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and positive data on mutagenicity tests in vitro (reverse mutation tests and chromosome aberration tests), described in CERI Hazard Data 2000-41 (2001).
6 Carcinogenicity Classification not possible - - - - Cannot be classified given the insufficiency of data for use in classification along with the absence of existing classification.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (nervous system, blood system), Category 3 (respiratory tract irritation) Danger
Warning
H370: Causes damage to organs (nervous system, blood system)
H335: May cause respiratory irritation (respiratory tract irritation)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the human evidence including "irritation to the eye/airway/skin, cyanosis of the lips/nails/skin, dizziness, headache, smothering feeling, nausea, vomiting, acute visual impairment," "may affect the blood system and produce methemoglobin" (MOE Risk Assessment vol.3 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (blood system), Category 2 (nervous system) Danger
Warning
H372: Cause damage to organs through prolonged or repeated exposure (blood system)
H373: May cause damage to organs through prolonged or repeated exposure (nervous system)
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "retrobulbar neuritis" (HSDB (2002)), "may affect the nervous system and cause visual impairment" (ICSC (J) (1999)), and the evidence from animal studies including "abnormal behaviour, congestion of the visible mucosa, dyspnea, decreases in hemoglobin concentration/RBC count, sulfhemoglobinemia" (MOE Risk Assessment vol.3 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 72 hours ErC50=0.14mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1999).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (BCF<44(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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