GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：cis-1,2-Dichloroethylene
CAS：156-59-2
Result：
| ID: | 396 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 6 | Flammable liquids | Category 2 |
|
Danger | H225: Highly flammable liquid and vapour |
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P233: Keep container tightly closed. P240: Ground/bond container and receiving equipment. P241: Use explosion-proof electrical/ventilating/lighting/.../equipment. P242: Use only non-sparking tools. P243: Take precautionary measures against static discharge. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
The flash point is 6degC (c.c.) and the boiling point is 60degC (ICSC (2003)), which is classified into Category 2. Classified as Class 3 and Packing Group II (UN#1150: 1,2-dichloroethylene) (UN Recommendations on the Transport of Dangerous Goods). |
| 7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | No data available, though containing unsaturated bonds. Classified as Class 3 (UN#1150: 1,2-dichloroethylene) (UN Recommendations on the Transport of Dangerous Goods). |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 460degC (1,2-dichloroethylene (ICSC, 2003)). |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing chlorine (but not oxygen and fluorine), with the chlorine bound to carbon and hydrogen (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Not classified | - | - | - | - | Classified into Class 3 (UN#1150: 1,2-dichloroethylene) (UN Recommendations on the Transport of Dangerous Goods). |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Not classified | - | - | - | - | Based on the rat LC50 (4 hour-inhalation of vapour) value of 13,700ppm (MOE Risk Assessment vol. 2 (2003)) was lower than 90% of the saturated vapour concentration (264,000ppm) under a saturated vapour pressure of 26.7kPa (25degC), the substance was classified based on standard values expressed in ppm. |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | Classification not possible due to the insufficiency of data, though human epidemiological studies provide evidence of "irritation of the eye and skin following application of aqueous solutions" (MOE Risk Assessment vol. 2 (2003)). |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | Classification not possible due to the insufficiency of data, though human epidemiological studies provide evidence of "irritation of the eye and skin following application of aqueous solutions" (MOE Risk Assessment vol. 2 (2003)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Category 2 |
|
Warning | H341: Suspected of causing genetic defects |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (chromosome aberration tests), described in NTP TR55 (2002), ATSDR (1996) and CERI Hazard Data 2000-46 (2001). |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category D by EPA (1995). |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Insufficient data available |
| 8 | Specific target organ toxicity - Single exposure | Category 3 （Narcotic effects） |
|
Warning | H336: May cause drowsiness or dizziness (narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies "In the 8,000ppm dose group, narcotic effects and some death were observed at 4 hours. In the 16,000ppm dose group, narcotic effects occurred within 8 minutes; deaths were observed at 4 hours" (PATTY (4th, 2000)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (blood system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "decreased hematocrit levels/RBC" (ATSDR (1996)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2. |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Not classified | - | - | - | - | It was classified into Not classified from 96 hours LC50=135mg/L of the fish (Bluegill) (CERI Hazard Data, 2002). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since it was not water-insolubility (the water-solubility =6410mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |