GHS Classification Result

Chemical Name：1,3-Dichloro-2-propanol
CAS：96-23-1

Result：
ID: 405
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Category 4 - Warning H227: Combustible liquid P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ... 		The flash point is 74degC (open cup flash test) (NFPA (13th, 2002)), which is classified into Category 4.
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Classified into Division 6.1 (UN#2750) (UN Recommendations on the Transport of Dangerous Goods).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine), with the oxygen and chlorine bound to carbon and hydrogen respectively (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#2750) (UN Recommendations on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 81mg/kg representing the lower of the two testing data of rat LD50 (oral route) of 81mg/kg (MOE Risk Assessment vol. 4 (2005)) and 122mg/kg (CERI Hazard Data 97-10 (1998)).
1 Acute toxicity （Dermal） Category 3 Danger H311: Toxic in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 500mg/kg representing the lower of the two testing data of rabbit LD50 (dermal route) of 500mg/kg (CERI Hazard Data 97-10 (1998)) and 590mg/kg (MOE Risk Assessment vol. 4 (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LC50 (4 hours) value of 32.5ppm, calculated from the testing data of rat LC50 (4-hour inhalation of vapour) of 125mL/m3 (DFGOT vol.1 (1990)), was lower that 90% of the saturated vapour concentration (9,000ppm) under a saturated vapour pressure of 0.9kPa (20degC), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 97-10 (1998) and CERI-NITE Hazard Assessment No.201 (2004)): "moderate damage" and "irritation" (though recovery period is not presented). The substance is thus considered a skin irritant (though the results are not those of 4-hour application).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 97-10 (1998) and CERI-NITE Hazard Assessment No.201 (2004)): "strong irritation," "severe irritation" (though recovery period is not presented). The substance is thus considered irritating to the eye (though the results are not those of 4-hour application).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in MOE Risk Assessment vol. 4 (2005), CERI-NITE Hazard Assessment No.201 (2005) and DFGOT Vol.1 (1991).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment, in the absence of existing classification except EU risk phrase.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 1 (liver) Danger H370: Causes damage to organs (liver) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence: "some cases diagnosed as acute fulminant hepatitis" (CERI-NITE Hazard Assessment No.201 (2004)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver, kidney, blood system), Category 2 (respiratory system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney, blood system)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "histopathological changes in the liver and kidney (multifocal renal tubular degeneration etc.), histopathological changes in the nasal passage (turbinate adhesion, nasal mucosal degeneration, hyperplasia of the respiratory/nasal mucosa), decreased hemoglobin/hematocrit levels, reduced RBC in females, fatty degeneration of hepatocytes" (CERI-NITE Hazard Assessment No.201 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (liver, kidneys, blood system) and Category 2 (respiratory organs).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Not classified - - - - It was classified into Not classified from 96 hours LC50>100mg/L of the fish (Oryzias Latipest) (MOE eco-toxicity tests of chemicals, 1996).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since it was not water-insolubility (the water-solubility =99000mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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