Chemical Name：O-2,4-dichlorophenyl O-ethyl S-propyl phosphorodithioate
CAS：34643-46-4

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 1,700mg/kg (Agricultural Chemical Registration Data (1971)).
1	Acute toxicity （Dermal）	Category 5	-	Warning	H313: May be harmful in contact with skin	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LD50 (dermal route) value of 3,900mg/kg (Agricultural Chemical Registration Data (1971)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >2.7mg/L (Agricultural Chemical Registration Data (1988)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1975)).
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Based on the evidence of irritation reactions which disappeared after 2-3 days, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1975)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Category 1		Warning	H317: May cause an allergic skin reaction	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ...	Based on positive results in guinea pig skin sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1988)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro assays (reverse mutation tests and chromosome aberration tests) and in vivo assays (mouse chromosome aberration tests and dominant lethal tests) (Agricultural Chemical Registration Data (1975, 1977, 1978, 1988)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no evidence of treatment-related incidence of tumor formation observed in 18-month (rats and mice) carcinogenicity studies (Agricultural Chemical Registration Data (1978, 1979)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on parental reproduction and offspring development observed in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1977, 1979)).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system)		Warning	H371: May cause damage to organs (nervous system)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "slow movement," "piloerection," "crouching," "diarrhea," "salivation," "reduced weight," "straub tail," and "convulsions" (Agricultural Chemical Registration Data (year unknown))." These effects were observed at dosing levels within the guidance value ranges for Category 2.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Insufficient data available
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48 hours EC50=0.002mg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.67 (PHYSPROP Database, 2005)), it was classified into Category 1.