GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：3,4-Dinitrotoluene
CAS：610-39-9
Result：
| ID: | 415 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not classified | - | - | - | - | Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups with its oxygen budget calculated at -114, and may explode if heated according to ICSC (2004)). Classified as Division 6.1 (UN#3454 (solid) and UN#1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 7 | Flammable solids | Not classified | - | - | - | - | Classified as flammable according to ICSC (2004). Classified intoo Division 6.1 (UN#3454 (solid) and UN#1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
| 8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | Containing nitro groups with explosive properties. The substance may explode if heated according to ICSC (2004). Classified into Division 6.1 (UN#3454 (solid) and 1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Classified into Division 6.1 (UN#3454 (solid) and 1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 58degC (ICSC, 2004), test temperature: 140degC). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 14 | Oxidizing solids | Not classified | - | - | - | - | No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#3454 (solid) and 1600 (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 807mg/kg calculated from the testing data of rat LD50 (oral route) of 807mg/kg, 1,072mg/kg and 907mg/kg (DFGOT vol.6 (1994)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on the positive results in skin sensitization studies with guinea pigs (Maximization Tests) (CERI-NITE Hazard Assessment No.51 (2004)). |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in NTP DB (Access on April 2006). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system, cardiovascular system, blood system), Category 3 (narcotic effects) |
|
Warning |
H371: May cause damage to organs (central nervous system, cardiovascular system, blood system) H336: May cause drowsiness or dizziness (narcotic effects) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Also based on the evidence from animal studies including "somnolency " (RTECS (1999)). Refer to "Dinitrotoluene (ID_0413, CAS_25321-14-6)." |
| 9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system, cardiovascular system, blood system) |
|
Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, cardiovascular system, blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Refer to "Dinitrotoluene (ID_0413, CAS_25321-14-6)." |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96 hours EC50=0.74mg/L of the algae (Chlorella) (CERI/NITE Hazard Assessment Report, 2004). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 1 |
|
Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity is Category 1 and bio-accumulation is low (BCF<2.7(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |