NITE - Chemical Management Field

GHS Classification Result

Chemical Name：3,5-Dinitrotoluene
CAS：618-85-9

Result：


ID:	416
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not classified	-	-	-	-	Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -114). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Not classified	-	-	-	-	Classification not possible due to lack of data, though classified as flammable according to HSDB (2006). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
8	Self-reactive substances and mixtures	Not classified	-	-	-	-	No data available, though the substance contains nitro groups with explosive properties. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Not classified	-	-	-	-	Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available (melting point: 93degC (HSDB, 2006), test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not classified	-	-	-	-	No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 216mg/kg representing the lower of the two testing data, 216mg/kg and 309mg/kg (DFGOT vol.6 (1994)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available. As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	Insufficient data available
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data on multi-generation mutagenicity tests (dominant lethal tests) and the absence of data on germ/somatic cell mutagenicity tests in vivo, described in DFGOT vol.6 (1994), NITE Initial Risk Assessment No.51 (2005), IARC 65 (1996) and CERI-NITE Hazard Assessment No.51 (2004).
6	Carcinogenicity	Not classified	-	-	-	-	Due to the fact that the substance is classified as Group 3 by IARC (1996).
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "somnolency" (RTECS 1999). Refer to "Dinitrotoluene (CAS_25321-14-6)."
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Classification not possible due to lack of data on 3,5-dinitrotoluene per se. Refer to "Dinitrotoluene (CAS_25321-14-6)."
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 3	-	-	H402: Harmful to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 3 from 96 hours LC50=22.0mg/L of the fish (Fathead Minnows) (CERI/NITE Hazard Assessment Report, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 3	-	-	H412: Harmful to aquatic life with long lasting effects	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	Although acute toxicity was Category 3 and the bio-accumulation potential was low (log Kow=2.18(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI/NITE Hazard Assessment Report, 2004)), it was classified into Category 3.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）