GHS Classification Result

Chemical Name：2,5-Dinitrotoluene
CAS：619-15-8

Result：
ID: 417
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -114). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classification not possible due to lack of data, though classified as flammable according to HSDB (2006). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not classified - - - - No data available, though the substance contains nitro groups with explosive properties. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 52.5degC (HSDB, 2006), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Not classified - - - - Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 557mg/kg calculated from the testing data of rat LD50 650mg/kg, 707mg/kg, 616mg/kg (DFGOT vol.6 (1994)) and 517mg/kg (MOE Risk Assessment vol. 4 (2005)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available. As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
3 Serious eye damage/eye irritation Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
6 Carcinogenicity Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
7 Reproductive toxicity Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of "somnolency" from animal studies (RTECS (2006)). Refer to "Dinitrotoluene (CAS_25321-14-6)."
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to lack of data on 2,5-dinitrotoluene per se. Refer to "Dinitrotoluene (CAS_25321-14-6)."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=1.3mg/L of the fish (Fathead Minnows) (CERI/NITE Hazard Assessment Report (2004) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (log Kow=2.18(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI/NITE Hazard Assessment Report, 2004)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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