GHS Classification Result

Chemical Name:2,3-Dinitrotoluene
CAS:602-01-7

Result:
ID: 418
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not classified - - - - Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -114). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classification not possible due to lack of data, though classified as flammable according to ICSC (2004). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not classified - - - - No data available, though the substance contains nitro groups with explosive properties. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 59-61degC (ICSC, 1999), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not classified - - - - No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the LD50 value of 935mg/kg calculated from the testing data of rat LD50 (oral route) of 911mg/kg, 1,112mg/kg and 1,102mg/kg (DFGOT vol.6 (1994)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - No data available. As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
3 Serious eye damage/eye irritation Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in NTP DB (Access on April 2006).
6 Carcinogenicity Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
7 Reproductive toxicity Classification not possible - - - - No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6."
8 Specific target organ toxicity - Single exposure Category 2 (central nervous system, cardiovascular system, blood system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (central nervous system, cardiovascular system, blood system)
H336: May cause drowsiness or dizziness (narcotic effects)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Also based on the evidence from animal studies including "somnolency " (RTECS (2006)). Refer to "Dinitrotoluene (CAS_25321-14-6)."
9 Specific target organ toxicity - Repeated exposure Category 2 (central nervous system, cardiovascular system, blood system) Warning H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, cardiovascular system, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Refer to "Dinitrotoluene (CAS_25321-14-6)."
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=0.33mg/L of the fish (Bluegill) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.18(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI/NITE Hazard Assessment Report, 2004)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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