Chemical Name:2,3-Dinitrotoluene
CAS:602-01-7
ID: | 418 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not classified | - | - | - | - | Because of a lack of data on the kick-off temperature and decomposition energy (though the substance contains nitro groups, with its oxygen budget calculated at -114). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Classification not possible due to lack of data, though classified as flammable according to ICSC (2004). Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and UN#1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
8 | Self-reactive substances and mixtures | Not classified | - | - | - | - | No data available, though the substance contains nitro groups with explosive properties. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available (melting point: 59-61degC (ICSC, 1999), test temperature: 140degC). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not classified | - | - | - | - | No data available, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen. Classified into Division 6.1 (UN#3454 Dinitrotoluene (solid) and 1600 Dinitrotoluene (molten)) (UN Recommendations on the Transport of Dangerous Goods). |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 935mg/kg calculated from the testing data of rat LD50 (oral route) of 911mg/kg, 1,112mg/kg and 1,102mg/kg (DFGOT vol.6 (1994)). | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available. As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | Insufficient data available |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in NTP DB (Access on April 2006). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID413, Dinitrotoluene, CAS: 25321-14-6." |
8 | Specific target organ toxicity - Single exposure | Category 2 (central nervous system, cardiovascular system, blood system), Category 3 (narcotic effects) | Warning |
H371: May cause damage to organs (central nervous system, cardiovascular system, blood system) H336: May cause drowsiness or dizziness (narcotic effects) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Also based on the evidence from animal studies including "somnolency " (RTECS (2006)). Refer to "Dinitrotoluene (CAS_25321-14-6)." | |
9 | Specific target organ toxicity - Repeated exposure | Category 2 (central nervous system, cardiovascular system, blood system) | Warning | H373: May cause damage to organs through prolonged or repeated exposure (central nervous system, cardiovascular system, blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence: "adversely affects the central nervous system, cardiovascular system and blood, and may produce methemoglobin" (ICSC (J) (1997)). Refer to "Dinitrotoluene (CAS_25321-14-6)." | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 96 hours LC50=0.33mg/L of the fish (Bluegill) (CERI/NITE Hazard Assessment Report, 2004). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.18(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI/NITE Hazard Assessment Report, 2004)), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
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