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GHS Classification Result

Chemical Name：Tributyltin chloride
CAS：1461-22-9

Result：


ID:	428
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
6	Flammable liquids	Classification not possible	-	-	-	-	No data available. The flash point of some products on the market is over 110degC (c.c.) (Sigma-Aldrich MSDS, 2004), which is "Not classified."
7	Flammable solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Classification not possible	-	-	-	-	No data available
10	Pyrophoric solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test methods applicable to liquid substances are not available.
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Stable to water (insoluble in cold water, HSDB (2006))
13	Oxidizing liquids	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though being organic compounds containing chlorine bound to elements other than carbon and hydrogen.
14	Oxidizing solids	Not applicable	-	-	-	-	Classified as "liquid" according to GHS definition
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 3		Danger	H301: Toxic if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) of 122mg/kg representing the lower of the two testing data, 122mg/kg (EHC 116 (1990)) and 129mg/kg (EHC 116 (1990)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	Based on the description in the report on rat skin irritation tests (EHC 116 (1990)): "The substance induced widespread epidermal necrosis within 12-24 hours. Regeneration of the epidermal layer was observed at 18-24 hours. No inflammatory infiltration was found in the dermis. At 5 hours, erythema reached a maximum and remained through 48 hours. By 72 hours, erythema reactions had resolved." The substance is thus considered to cause strong irritation with reversible effects, and classified into Category 2.
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the description of the human health effects (HSDB (2006)): "severely irritating to the eye."
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	No data available As for the health hazards, refer to "ID1275, Tributyltinoxide, CAS: 56-35-9."
6	Carcinogenicity	Classification not possible	-	-	-	-	No data available As for the health hazards, refer to "ID1275, Tributyltinoxide, CAS: 56-35-9."
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available As for the health hazards, refer to "ID1275, Tributyltinoxide, CAS: 56-35-9."
8	Specific target organ toxicity - Single exposure	Category 2 (liver, kidney)		Warning	H371: May cause damage to organs (liver, kidney)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "steatosis of the hepatocyte, traces of lipid in renal tubules, haemorrhages in the gastrointestinal tract and kidney" (EHC 116 (1990)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	No data available Refer to "ID1275, Tributyltinoxide, CAS: 56-35-9."
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=1.1microg/L of the crustacea (Mysid Shrimp)) (EHC116 (1990) and others.).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (it was hydrolyzed, and triphenyltin hydroxide was generated, and was residue(existing chemical safety inspections data)), and since there was bio-accumulation (BCF=9210(triphenyltin hydroxide) (existing chemical safety inspections data)), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）