Chemical Name:O-4-bromo-2-chlorophenyl O-ethyl S-propyl phosphorothioate
CAS:41198-08-7
ID: | 433 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
6 | Flammable liquids | Classification not possible | - | - | - | - | Classification not possible due to lack of data. The reagent (purity: 98%) has the flash point of 100degC (c.c.) according to some reports, which could be "Not classified. " |
7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not classified | - | - | - | - | Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 150degC) (Agricultural Chemical Registration Data) |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Stable to heat (up to 150degC) (Agricultural Chemical Registration Data) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (water solubility: 28mg/L (22degC, pH6.9) (Agricultural Chemical Registration Data)) |
13 | Oxidizing liquids | Classification not possible | - | - | - | - | Cannot be classified though being organic compounds containing oxygen bound to elements other than carbon and hydrogen |
14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 510mg/kg (Agricultural Chemical Registration Data (1984)). | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rat LD50 (dermal route) value of >4,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1984)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 | Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the rat LC50 (inhalation route) value of 4.45mg/kg (Agricultural Chemical Registration Data (1984)). | |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the evidence of mild irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1984)). |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the evidence of mild irritation with the effects reversible within 4 days, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1988)). |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on positive results in guinea pig skin sensitization tests performed according to the Maximization method and OECD TG406 (Agricultural Chemical Registration Data (2004)). | |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data in in vitro chromosome aberration tests, in vitro reverse mutation tests (Agricultural Chemical Registration Data (1984)) and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (2004)). |
6 | Carcinogenicity | Not classified | - | - | - | - | There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1984)). |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1984)). |
8 | Specific target organ toxicity - Single exposure | Category 2 (nervous system) | Warning | H371: May cause damage to organs (nervous system) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence from animal studies including "lacrimation," "convulsions," "salivation," and "reduced motor functions" (Agricultural Chemical Registration Data (1984)). These effects were observed at dosing levels within the guidance value ranges for Category 2. | |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | In repeat dose toxicity studies in animals, cholinesterase inhibition was detected, but no target organs were identified from evidence reported (Agricultural Chemical Registration Data (1984)). |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48 hours EC50=0.84microg/L of the crustacea (Daphnia magna) (Agricultural Chemical Registration Data, 2005). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=4.68 (PHYSPROP Database, 2005)), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |