GHS Classification Result

Chemical Name:Decabromodiphenyl ether
CAS:1163-19-5

Result:
ID: 435
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Used as a flame retardant additive for polystyrene products etc. (HSDB, 2006)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures (Used as a flame retardant additive for polystyrene products etc. (HSDB, 2006)).
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 (oral route) value of > 5,000mg/kg (EHC 162 (1994)).
1 Acute toxicity (Dermal) Classification not possible - - - - Insufficient data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - Insufficient data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (EHC 162 (1994)): "The substance initially caused no irritation of the skin. After an observation period of 72 hours, slight erythematous and edematous responses were noted."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on rabbit eye irritation tests (EHC 162 (1994), CERI-NITE Hazard Assessment No.56 (2005)): "Animals treated with the substance showed only transient congestion and edema of the conjunctival membranes. These symptoms subsided by 24 hours," "At 24 hours, only slight redness (4 of 6), only slight edema (2 of 6), and only slight discharge (1 of 6) of the conjunctiva were noted." The substance is thus considered a mild eye irritant.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the negative results in human skin sensitization tests (CERI Hazard Data 97-16 (1998) and EHC 162 (1994)).
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence of data on multi-generation mutagenicity tests, germ cell mutagenicity tests in vivo and germ cell genotoxicity tests in vivo, and positive data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in NITE Initial Risk Assessment No.56 (2005), CERI-NITE Hazard Assessment No.56 (2005), EU-RAR No.17 (2002) and NTP DB (Access on April 2006).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC (1999) and Category C by EPA (1990).
7 Reproductive toxicity Not classified - - - - Based on no definitive evidence of reproductive toxicity observed in reproductive toxicity studies and teratogenicity studies in rats and mice, described in NITE Initial Risk Assessment No.56 (2005) and CERI-NITE Hazard Assessment No.56 (2005).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available
9 Specific target organ toxicity - Repeated exposure Category 2 (liver, kidney, thyroid) Warning H373: May cause damage to organs through prolonged or repeated exposure (liver, kidney, thyroid) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies including "hypertrophy and vacuolization of centrolobular hepatocytes in the liver, renal tubular hyaline degeneration, and hyperplasia of the thyroid gland" (MOE Risk Assessment vol. 2 (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - Since 72 hours EC50 of the algae (Skeletonema) was more than the water solubility (EU-RAR (2003)), it was classified into Not classified.
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Although it is water-insolubility and acute toxicity was not reported within the aqueous solubility concentrations and there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), since the bio-accumulation (BCF<50 (Existing Chemical Safety Inspections Data)) was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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