GHS Classification Result

Chemical Name：Tetrachloroisophthalonitrile
CAS：1897-45-6

Result：
ID: 437
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (IUCLID (2000))
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-flammable (IUCLID (2000))
11 Self-heating substances and mixtures Not classified - - - - Non-flammable (IUCLID (2000))
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing chlorine (but not fluorine and oxygen), with the fluorine bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 252.1degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Not classified - - - - Based on the rat LD50 (oral route) value of >10,000mg/kg (Agricultural Chemical Registration Data (1973)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rat LD50 (dermal route) value of >10,000mg/kg (Agricultural Chemical Registration Data (2004)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 (inhalation route) value of 0.1mg/L (4 hours) (EHC183 (1996)).
2 Skin corrosion/irritation Classification not possible - - - - The available rabbit skin irritation tests demonstrated mild reversible irritation: mild erythema observed in all treated animals receiving 24 hour application (though the effects cleared up after 2-7 days) and mild to moderate edema in most animals exposed to >2.15g/kg (though the effects resolved after 1-2 days) (Agricultural Chemical Registration Data (1973)). However, given the high doses of application (1.0g/rabbit at a minimum) and long exposure duration (24 hours), it is decided not to use these findings for classification.
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on the evidence of moderate irritation which persisted for up to day 7, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1973)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on positive results in skin sensitization tests with chlorothalonil (neat) in Hartley guinea pigs, though skin photosensitivity tests in guinea pigs using the Herber method showed negative.
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro reverse mutation tests (Agricultural Chemical Registration Data (1983)), mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1985)), and in vivo chromosome aberration tests performed in rats and hamsters (Agricultural Chemical Registration Data (1995)).
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category 2B by IARC (1999) and Category 2B by the Japan Society for Occupational Health.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of increased early embryonic mortality at doses causing reduced parental body weight gains observed in rat teratogenicity studies (Agricultural Chemical Registration Data (1985)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - Insufficient data available: the different routes of exposure resulted in substantial differences in the degree of toxicity (the dermal LD50 was >=10,000mg/kg without any noted symptoms of toxicity, whereas the inhalation LC50 was 0.1mg/L (Agricultural Chemical Registration Data, 1973)).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - In rat acute toxicity studies, proventricular changes probably due to irritation was observed at doses within the guidance value ranges for Category 1. However, no other findings referable to specific target organs were reported (Agricultural Chemical Registration Data (1988)) and insufficient data are available.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96 hours LC50=10.5microg/L of the fish (Rainbow Trout) (MOE Risk Assessment vol. 2 (2003) and others.).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (BCF=125(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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