GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Tetrachlorodifluoroethane; CFC-112
CAS：
Result：
| ID: | 438 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-flammable (ICSC (2004)). |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-flammable (ICSC (2004)). |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-flammable (ICSC (2004)). |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing fluorine and chlorine (but not oxygen), with the fluorine and chlorine bound to carbon and hydrogen (but not to other elements) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available on substances with melting point of <55degC (melting point: 40.6degC (1,2,2,2-tetrachloro-1,1-difluoroethane, ICSC (2004)), melting point: 26degC (1,1,2,2-tetrachloro-1,2-difluoroethane, ICSC (2004))). |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 |
|
Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
1,1,1,2-Tetrachloro-2,2-difluoroethane yields the rat LD50 (oral route) value of >8,000mg/kg (HSDB (2006)), which is "Not classified." 1,1,2,2-Tetrachloro-1,2-difluoroethane yields the mouse LD50 (oral route) value of 800mg/kg (HSDB (2006)), which is classified as Category 4. Based on the lower of the two testing data (800mg/kg), tetrachlorodifluoroethane is included in Category 4. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Classification not possible | - | - | - | - | Due to the fact that the substance is a solid according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Category 5 | - | Warning | H333: May be harmful if inhaled | P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. | 1,1,1,2-Tetrachloro-2,2-difluoroethane yields the rat LC50 (inhalation route) value of 125.04mg/L (4 hours) (ACGIH (7th, 2001)), which is classified as Category 5 (saturated vapour concentration of 659mg/L under a saturated vapour pressure of 8.00 kPa (25degC) (HSDB (2006))). 1,1,2,2-Tetrachloro-1,2-difluoroethane yields the LC50 value of 25mg/L (4 hours) calculated from the mouse LC50 of 50mg/L (2 hour inhalation) (RTECS (2006)), which is classified as Category 5 (saturated vapour concentration of 555mg/L under a saturated vapour pressure of 6.73kPa (25degC) (HSDB (2006))). |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in the report on rabbit skin irritation tests (EHC (1990)): Caused "histological changes in skin musculature" (1,1,1,2-Tetrachloro-2,2-difluoroethane). Based on the description in the report on rabbit skin irritation tests (exposure duration unknown) (EHC (1990)): Caused "skin erythema but no systematic or histological effects." Also based on the evidence of "mild" irritation from guinea pig skin irritation tests (24 hour application) and the evidence of human health effects: "Mildly irritating to the respiratory tract and skin" (RTECS (2006)) (1,1,2,2-Tetrachloro-1,2-difluoroethane). |
| 3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in the report on rabbit eye irritation tests (HSDB (2006)): "Mild conjunctival irritation." Also based on the description of the human health effects (HSDB (2006)): "Mildly irritating to the eye." The substance is thus considered a mild eye irritant (1,1,2,2-Tetrachloro-1,2-difluoroethane). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | According to the description in EHC (1990), a skin sensitization tests showed no indication of sensitization in guinea pigs. However, classification is not possible, with only one set of data showing "negative" available (1,1,2,2-Tetrachloro-1,2-difluoroethane). |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), described in EHC 113 (1990), DFGOT vol.1 (1990) and NTP DB (Access on July 2006). |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible based on expert judgment in the absence of existing classification, though EHC 113 (1990) and DFGOT vol.1 (1990) provide some toxicity data. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | No data available |
| 8 | Specific target organ toxicity - Single exposure | Category 2 (respiratory system, cardiovascular system, central nervous system) |
|
Warning | H371: May cause damage to organs (respiratory system, cardiovascular system, central nervous system) |
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "Acute inhalation exposure to high concentrations can cause pulmonary edema; may adversely affect the cardiovascular/central nervous system, causing cardiopathy and central nervous depression; may involve a lowering of consciousness" (ICSC (J) (2003)). However, since the referenced study is assigned a priority rating of 2, these effects are classified into Category 2. |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data available |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |