Chemical Name:Tetrahydromethylphthalic anhydride
CAS:11070-44-3
ID: | 439 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
6 | Flammable liquids | Not classified | - | - | - | - | The flash point is 157degC (open cup flash test) (SIDS (2005)) |
7 | Flammable solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
8 | Self-reactive substances and mixtures | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though containing unsaturated bonds (olefin) |
9 | Pyrophoric liquids | Classification not possible | - | - | - | - | No data available |
10 | Pyrophoric solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available. |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
14 | Oxidizing solids | Not applicable | - | - | - | - | Classified as "liquid" according to GHS definition |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the LD50 value of 1,930mg/kg calculated from the testing data of rat LD50 (oral route) of 1,900mg/kg, 2,102mg/kg and 2,140mg/kg (SIDS (2005)). | |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | No data available |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Based on the description in the report on rabbit skin irritation tests (SIDS (2005)): "moderate irritant" (though the results are not those of 4 hour application). | |
3 | Serious eye damage/eye irritation | Category 2A | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the evidence from rabbit eye irritation tests (SIDS (2005)): The substance induced irritation of the eye. The effects were not fully reversible on day 10. | |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Based on several epidemiological case reports that suggest respiratory sensitization in humans (CERI Hazard Data 2001-62 (2002) and MOE Risk Assessment vol. 4 (2005)). | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Based on several epidemiological case reports that suggest skin sensitization in humans (CERI Hazard Data 2001-62 (2002) and MOE Risk Assessment vol. 4 (2005)). | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo, germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in CERI Hazard Data 2001-62 (2002), Report by the Ministry of Health, Labour and Welfare (1997) and SIDS (2005). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | No data available |
7 | Reproductive toxicity | Classification not possible | - | - | - | - | Insufficient data available |
8 | Specific target organ toxicity - Single exposure | Category 3 (Respiratory tract irritation, Narcotic effects) | Warning |
H335: May cause respiratory irritation (respiratory tract irritation, narcotic effects) H336: May cause drowsiness or dizziness (respiratory tract irritation, narcotic effects) |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "The present substance has been known to show strong irritancy, and numerous clinical signs in the eye and respiratory tract have been reported as key effects" (CERI Hazard Data 2001-62 (2002)), and the evidence from animal studies including "reduced activity, bradypnea and prone position, which is reversible within three days" (Report by the Ministry of Health, Labour and Welfare (1997)). | |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data available |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 3 | - | - | H402: Harmful to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 3 from 24-48 hours ErC50=55mg/L of the algae (Selenastrum) (SIDS, 2005). |
11 | Hazardous to the aquatic environment (Long-term) | Category 3 | - | - | H412: Harmful to aquatic life with long lasting effects |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
Although acute toxicity was Category 3 and the bio-accumulation potential was low (BCF<2.4(CERI Hazard Data, 2002)), since there was no rapidly degrading (the decomposition by BOD: 0%(CERI Hazard Data, 2002)), it was classified into Category 3. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |