GHS Classification Result

Chemical Name：Dimethyl terephthalate
CAS：120-61-6

Result：
ID: 440
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as "flammable" by ICSC (2004)
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 518degC (ICSC, 2004)
11 Self-heating substances and mixtures Classification not possible - - - - No data available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (oral route) value of 4,390mg/kg (SIDS (2005)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the guinea pig LD50 (dermal route) value of >5,000mg/kg (SIDS (2001)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the descriptions in the report on skin irritation tests in rabbits and guinea pigs (CERI Hazard Data 98-18 (1999)) (exposure duration not presented): "mild irritation," "transient hyperpigmentation and weak irritation at the site of contact." The substance is thus considered a mild skin irritant (though it is unclear whether the results are those of 4-hour application).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in the report on rabbit eye irritation tests (exposure duration not presented) (SIDS (2005)): "mildly irritating," "conjunctivitis (recovery period unknown)." Also based on the description of the human health effects (MOE Risk Assessment vol. 3 (2004)): "reddening of the eye." The substance is thus considered a mild irritant.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the description in CERI Hazard Data 98-18 (1999) and SIDS (2005): "Skin sensitization: negative," "DMT does not induce allergic contact sensitization."
5 Germ cell mutagenicity Not classified - - - - Based on negative data on somatic cell mutagenicity tests in vivo (mouse micronucleus tests), described in SIDS (2005) and NTP DB (Access on Feb., 2006). The substance showed equivocal data on mouse chromosome aberration tests which were not considered to indicate a mutagenic potential. Also, negative results were reported in in vitro mutagenicity tests (reverse mutation tests, chromosome aberration tests and mutation tests).
6 Carcinogenicity Classification not possible - - - - Classification not possible given the insufficiency of data for use in classification, along with the absence of existing classification.
7 Reproductive toxicity Not classified - - - - Based on no definitive evidence of reproductive/developmental toxicity at doses producing parental toxicity, described in SIDS (2005), MOE Risk Assessment vol. 3 (2004) and CERI Hazard Data 98-18 (1999).
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence: "respiratory irritation through inhalation of fumes or dusts" (CERI Hazard Data 98-18 (1999)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, blood system, respiratory system, liver, kidney) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, blood system, respiratory system, liver, kidney) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "suppression of the nervous system function, mild anemia, reticulocytosis, hypertonia, chronic inflammation of the respiratory system," "rhinitis, tracheitis, pulmonary inflammation/emphysema, degeneration of the liver and kidney" (CERI Hazard Data 98-18 (1999)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 96 hours LC50=9.6mg/L of the fish (Fathead Minnows) (SIDS, 2005).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Since there was rapidly degrading (the decomposition by BOD: 84% (Existing Chemical Safety Inspections Data)) and the bio-accumulation was low (log Kow=2.25 (PHYSPROP Database, 2005)), it was claasified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information