GHS Classification Result

Chemical Name:Trichloroacetaldehyde
CAS:75-87-6

Result:
ID: 441
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Classification not possible - - - - No data available
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Classification not possible - - - - No data available. Those containing stabilizers are classified into Division 6.1 (UN#2075) (UN Recommendations on the Transport of Dangerous Goods).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine), with the oxygen and chlorine bound to carbon and hydrogen respectively (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available. Those containing stabilizers are classified into Division 6.1 (UN#2075) (UN Recommendations on the Transport of Dangerous Goods).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ...
Based on the rat LD50 (oral route) value of 480mg/kg (CICAD 25 (2000)).
1 Acute toxicity (Dermal) Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the guinea pig LD50 (dermal route) value of 1,510mg/kg representing the lower of the two testing data, 1,510mg/kg and 15,000mg/kg (CERI Hazard Data 2000-52 (2001)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition.
1 Acute toxicity (Inhalation: Vapours) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the rat LC50 value of 0.44mg/L (equivalent to 73ppm), representing the lower of the two testing data of rat LC50 (inhalation of vapour) of 2.12mg/L (4 hours) (CERI Hazard Data 2000-52 (2001)) and 0.44mg/L (MOE Risk Assessment vol. 3 (2004)), was lower than 90% of the saturated vapour concentration (47,000ppm) under a saturated vapour pressure of 4.7kPa (20degC) (CERI Hazard Data 2000-52 (2001)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description of the human health effects (CERI-NITE Hazard Assessment No.97 (2004)): "Chloral hydrate has a potential for skin and mucosal irritation, and at clinical doses, abdominal pain, nausea and vomiting may occur." The substance is thus considered a skin irritant, but classified into Category 3 in the absence of data on the degree of irritation. According to NITE Initial Risk Assessment No.97 (2005), "trichloroacetaldehyde rapidly reacts in vivo with water to form chloral hydrate." However, only those studies specifying "trichloroacetaldehyde" as the test material were used as a basis for classification.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description of the human health effects (CERI-NITE Hazard Assessment No.97 (2004)): "Chloral hydrate has a potential for skin and mucosal irritation, and at clinical doses, abdominal pain, nausea and vomiting may occur." The substance is thus considered a skin irritant, but classified into Category 2B in the absence of data on the degree of irritation. According to NITE Initial Risk Assessment No.97 (2005), "trichloroacetaldehyde rapidly reacts in vivo with water to form chloral hydrate." However, only those studies specifying "trichloroacetaldehyde" as the test material were used as a basis for classification.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the absence of data on multi-generation mutagenicity tests and positive data on germ cell mutagenicity tests in vivo (micronucleus tests), described in NITE Initial Risk Assessment No.97 (2005), NTP DB (Access on April 2006) and IARC 63 (1995).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 (CHLORAL AND CHLORAL HYDRATE) by IARC (2004).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of learning deficits in the offspring, described in MOE Risk Assessment vol. 2 (2003), CICAD 25 (2000) and IARC 63 (1995), though no data are available regarding the general conditions of parental animals.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the evidence from animal studies including "strong narcotic effects, vacuolization of Clara cells, alveolar necrosis, epithelial exfoliation and alveolar edema" (NITE Initial Risk Assessment No.97 (2005)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. According to NITE Initial Risk Assessment No.97 (2005), "trichloroacetaldehyde rapidly reacts in vivo with water to form chloral hydrate." However, only those studies specifying "trichloroacetaldehyde" as the test material were used as a basis for classification.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Classification not possible due to the insufficiency of data. According to NITE Initial Risk Assessment No.97 (2005), "trichloroacetaldehyde rapidly reacts in vivo with water to form chloral hydrate." However, only those studies specifying "trichloroacetaldehyde" as the test material were used as a basis for classification.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It was classified into Not classified from 48 hours EC50=112mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005) and others.).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since it was not water-insolubility (the water-solubility =30000mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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