GHS Classification Result

Chemical Name:Trichlorotrifluoroethane; CFC-113
CAS:

Result:
ID: 443
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Classification not possible - - - - Classification not possible due to lack of data. Classified as flammable under special conditions, according to ICSC (2004) (1,1,2-trichloro-1,2,2-trifluoroethane).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is used as cleaners (precision parts cleaning, metal cleaning, dry cleaning) (CERI Hazard Data (1999))
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: -36degC (1,1,2-trichloro-1,2,2-trifluoroethane, ICSC (2004)), 14.2degC (1,1,1-trichloro-2,2,2-trifluoroethane, HSDB (2006)), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing fluorine and chlorine (but not oxygen), with the fluorine and chlorine bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data. 1,1,2-trichloro-1,2,2-trifluoroethane is reported to act on magnesium and magnesium alloys (ICSC (2004)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (oral route) value of 43,000mg/kg (CERI Hazard Data 98-23 (1999)) (1,1,2-trichloro-1,2,2-trifluoroethane).
1 Acute toxicity (Dermal) Category 5 - Warning H313: May be harmful in contact with skin P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rabbit LD50 (dermal route) value of >11,000mg/kg (RTECS (2006)) (1,1,2-trichloro-1,2,2-trifluoroethane).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a liquid according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Category 5 - Warning H333: May be harmful if inhaled P304+P312: IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the LC50 value of 398.49mg/L calculated from the testing data of rat LC50 (inhalation route) of 398.49mg/L (CERI Hazard Data 98-23 (1999)), 409mg/L (calculated from 857mg/L (2 hours)), 428mg/L (EHC (1990)), 521.11mg/L (CERI Hazard Data 98-23 (1999)) (all 4 hour inhalation) (saturated vapour concentration of 3,672mg/L under a saturated vapour pressure (25degC) of 48.4kPa (363mmHg) (HSDB (2006)) (1,1,2-trichloro-1,2,2-trifluoroethane).
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests evaluated according to the Draize scheme (24 hour application) (CERI Hazard Data 98-23 (1999)): Caused "mild irritation" (1,1,2-trichloro-1,2,2-trifluoroethane).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
Based on the description in the report on rabbit eye irritation tests (DFGOT vol. 3 (1992)): Caused "mild conjunctivitis and a minimal corneal reaction." The substance is thus considered a mild eye irritant (1,1,2-trichloro-1,2,2-trifluoroethane).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - According to the descriptions in CERI Hazard Data 98-23 (1999) and IUCLID (2000), guinea pig skin sensitization tests using the Maximization method showed no indication of sensitization. However, classification is not possible, with only two sets of data showing "negative" available (1,1,2-trichloro-1,2,2-trifluoroethane).
5 Germ cell mutagenicity Not classified - - - - Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), the absence of data on in vivo germ/somatic cell mutagenicity tests, described in ACGIH (7th, 2001), EHC 113 (1990) and DFGOT vol.3 (1992).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Category A4 (as 1,1,2-trichloro-1,2,2-trifluoroethane (CAS: 76-13-1)) by ACGIH (7th, 2001).
7 Reproductive toxicity Not classified - - - - Based on no definitive evidence of toxic effects observed in rat and rabbit teratogenicity/reproduction studies, described in MOE Risk Assessment Vol. 4 (2005), ACGIH (7th, 2001) and CERI Hazard Data 98-23 (1999).
8 Specific target organ toxicity - Single exposure Category 1 (liver, respiratory system, central nervous system, blood system, gastrointestinal tract, cardiovascular system), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (liver, respiratory system, central nervous system, blood system, gastrointestinal tract, cardiovascular system)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the human evidence: "weak narcotic effects, and hypertrophy/lipogenesis of hepatocytes," "clinical symptoms including...pulmonary edema were noted," "clouding of consciousness and paleness were found; examination revealed hypochromic anemia and diffuse colitis," "temporary cyanosis was seen... ," "... lack of concentration occurred... and 10-30% decline in work efficiency was noted. Moreover, ... lethargy and a slight loss of orientation after shaking the head from left to right were found..." (MOE Risk Assessment Vol. 4 (2005)), "...some deaths due to asphyxiation or cardiac arrhythmia were reported" (EHC (1990)), "... adversely affects the cardiovascular system, central nervous system, induce cardiopathy and central nervous depression, and cause a lowering of consciousness; Acute symptoms include... cardiac arrhythmias, confusion, lethargy, short of breath and loss of consciousness by the inhalation route of exposure" (MOE Risk Assessment Vol. 4 (2005)).
9 Specific target organ toxicity - Repeated exposure Category 1 (central nervous system, liver) Danger H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence including "...emotional instability, chronic neuropsychological symptoms with learning disability, dysmnesia and concentration difficulties...," "mild elevation of AST and ALT, and mild hepatopathy with adipose infiltration" (CERI Hazard Data 98-23 (1999)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96 hours LC50=7.4mg/L of the fish (Rainbow Trout) (CERI Hazard Data, 1999).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=86(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 2%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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Model SDS by MHLW

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