GHS Classification Result

Chemical Name:alpha,alpha,alpha-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine
CAS:1582-09-8

Result:
ID: 446
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Classification not possible - - - - Classification not possible due to lack of data on the kick-off temperature and decomposition energy, though the substance contains nitro groups with its oxygen budget calculated at -143.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data, though classified as flammable according to ICSC (2004)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains nitro groups with explosive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Classification not possible - - - - Classification not possible due to lack of data
11 Self-heating substances and mixtures Classification not possible - - - - Test method applicable to liquid substances are not available (melting point: 47.2degC (Agricultural Chemical Registration Data), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Cannot be classified due to lack of data, though being organic compounds containing oxygen and fluorine (but not chlorine), with the oxygen bound to elements other than carbon and hydrogen.
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Classification not possible due to lack of data on the substances with melting points of <55degC (melting point: 47.2degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. Based on the rat LD50 (oral route) value of 2,517mg/kg (Agricultural Chemical Registration Data (1989)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1989)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >2.8mg/L (4 hours) (Agricultural Chemical Registration Data (1996)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the evidence of mild irritation, which were fully reversed within 14 days, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1989)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the evidence of mild irritation of the eye, which persisted for up to day 7, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1989)).
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on positive results in guinea pig skin sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1989)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro reverse mutation tests, in vitro chromosome aberration tests (Agricultural Chemical Registration Data (1989, 1997)) and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1997)).
6 Carcinogenicity Not classified - - - - There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1989)).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction or offspring development observed in rat reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1989)).
8 Specific target organ toxicity - Single exposure Classification not possible - - - - In single dose toxicity studies, the test animals demonstrated "lacrimation," "salivation," "blepharoptosis," "convulsions" and "spastic gait" (Agricultural Chemical Registration Data (1989)) indicative of nervous system effects. However, it was decided not to use these findings for classification since the exposure doses exceeded the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50<=5microg/L of the fish (Atlantic Clupea pallasii) (MOE Risk Assessment vol. 2, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since the acute toxicity was Category 1 and it had no rapidly degrading (the decomposition by BOD: 4% (Existing Chemicals Safety Check Data)), and it had the bio-accumulation (BCF=945 (Existing Chemicals Safety Check Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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