GHS Classification Result

Chemical Name：Nickel sulphate
CAS：7786-81-4

Result：
ID: 453
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Non-flammable (ICSC, 2004)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though being a sulfonyl, containing chemical groups with self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC, 2004)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC, 2004)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 40.4g/100g (25degC), Lide (84th, 2003))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though inorganic compounds containing oxygen
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 275mg/kg calculated from the testing data of rat LD50 (oral route) of 500mg/kg, 275mg/kg and 325mg/kg (ECETOC TR33 (1989)).
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Classification not possible - - - - Animal studies (rat skin irritation tests using cumulative application) (EHC 108 (1991)) and human epidemiological studies (EHC 108 (1991)) provide some evidence of irritation. However, classification is not possible in the absence of data on the severity of the effects.
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as a Respiratory Sensitizing Substance by DFG and "Respiratory Sensitizing Substance: Group 2" (as nickel compounds) according to the Recommendation on Occupational Exposure Limits for Chemical Substances (Japan Society for Occupational Health (2005)).
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as a Skin Sensitizing Substance by DFG and "Skin Sensitizing Substance: Group 1" (as nickel compounds) according to the Recommendation on Occupational Exposure Limits for Chemical Substances (Japan Society for Occupational Health (2005)).
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and negative data on germ cell mutagenicity tests in vivo (chromosome aberration tests) and somatic cell mutagenicity tests in vivo (micronucleus tests, chromosome aberration tests), described in IARC 49 (1990), ATSDR (2005) and EHC 108 (1991). As for the mutagenicity/genotoxicity of water-soluble inorganic nickel compounds, refer to "ID455, Nickel Chloride (II), CAS: 7718-54-9."
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Due to the fact that the substance is classified as Category K (as nickel compounds) by NTP (2005) and Category 1 (as nickel compounds) by IARC (1990).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of adverse effects on male reproductive function and pup development, described in EHC 108 (1991), IARC 49 (1990), ATSDR (2005), ACGIH (7th, 2001) and CERI Hazard Data 97-19 (1998).
8 Specific target organ toxicity - Single exposure Category 1 (central nervous system, respiratory system) Danger H370: Causes damage to organs (central nervous system, respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "nausea, abdominal spasm, diarrhea, vomiting, headache, dizziness, debility, myalgia" (ATSDR (2005)), "hemianopia" (IARC 49 (1990)), and the evidence from animal studies including "pulmonary hemorrhage" (ATSDR (2005)), "ataxia, swelling of the limbs, salivation" (CERI Hazard Data 97-19 (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. The acute toxicity of nickel compounds manifests in humans as "nausea, diarrhea, dizziness, headache" (ECETOC TR33 (1989)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, testis), Category 2 (liver) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, testis)
H373: May cause damage to organs through prolonged or repeated exposure (liver) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		The respiratory organs, kidney, testes and liver were considered to be the target organs based on reported effects including "increase in urinary levels of total proteins, beta2-microglobulin, retinol binding protein, and N-acetyl-beta-D-glucosaminidase (NAG)"(ATSDR (2005)) and "chronic rhinitis, nasal septal erosions, perforations and ulceration, allergic asthma and acute asthma"(EHC 108 (1991)) observed in human studies, and "decrease in number of bipolar receptor cells in nasal olfactory epithelium, alveolitis, atrophy of centrally located tubules"(ATSDR (2005)) and "vacuolation and deformation of hepatocytes, degeneration of the renal glomerulus, detachment of alveolar epithelium, alveolar wall thickening, emphysema and detachment of bronchial epithelium"(CERI hazard data collection 97-19 (1998)) observed in experimental animal studies. In experimental animals, these effects were observed at dosing levels within the guidance value ranges for Category 1 and for Category 2. Therefore the substance has been classified as Category 1 (respiratory organs, kidney and testes) and Category 2 (liver). The chronic toxicity of nickel compounds in humans is mentioned as follows: "Chronic exposure to nickel and its compounds may produce respiratory irritation and degeneration in humans even at doses close to occupational exposure limits. Prolonged exposure to high concentrations is likely to result in the fibroid lung"(ECETOC TR33 (1989)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 72 hours EC50=0.75mg/L of the algae (Selenastrum) (CERI Hazard Data, 1997).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 1 and bio-accumulation was low (BCF<31 (Existing Chemical Safety Inspections Data)), since it was a metallic compound and the underwater action was unknown, it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information