GHS Classification Result

Chemical Name：Zinc bis(N,N'-dimethyldithiocarbamate)
CAS：137-30-4

Result：
ID: 463
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as flammable according to ICSC (2004). Assigned to Division 6.1 (UN#2771 Thiocarbamate Pesticide (solid, toxic) (ICSC (2004))) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Assigned to Division 6.1 (UN#2771 Thiocarbamate Pesticide (solid, toxic) (ICSC (2004))) (UN Recommendations on the Transport of Dangerous Goods).
11 Self-heating substances and mixtures Not classified - - - - Assigned to Division 6.1 (UN#2771 Thiocarbamate Pesticide (solid, toxic) (ICSC (2004))) (UN Recommendations on the Transport of Dangerous Goods).
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 65mg/L (25degC), SRC (2006))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 594mg/kg calculated from the testing data of rat LD50 (oral route) of 500mg/kg, 1,400mg/kg, 1,750mg/kg, 650mg/kg and 267mg/kg (IUCLID (2000)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 (dermal route) values of >2,000mg/kg and >5,010mg/kg (IUCLID (2000).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Because the rat LC50 (inhalation of vapour) values of 0.07mg/L (4 hours) (IUCLID (2000)) and 0.081mg/L (4 hours) (IUCLID (2000)) exceeded 90% of the saturated vapour concentration of 9.9*10^(-6)ppm under a saturated vapour pressure of 7.5*10^(-9)mmHg (extrapolation) [equivalent to 1.0*10^(-6)Pa (extrapolation)] (SRC (2006)), the substance was considered as "mist exposure" and was classified as Category 2.
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on test data from rat skin irritation studies (exposure duration unknown) (IUCLID (2000)): "Mild irritation."
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		Based on test data from rabbit eye irritation studies (IUCLID (2000)): "Moderate to severe irritation." The substance is thus considered a "strong (though reversible) irritant" to the eye.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive data in multi-generation mutagenicity tests (dominant lethal tests), germ cell mutagenicity tests in vivo (chromosome aberration tests) and in vivo somatic cell mutagenicity tests (micronucleus tests), described in NTP DB (Access on July 2006), EHC 78 (1988) and IARC 53 (1991).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC (1991).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of visceral anomalies in the pups at doses producing parental toxicity in rat teratogenicity studies, described in IARC 53 (1991).
8 Specific target organ toxicity - Single exposure Category 1 (systemic toxicity), Category 2 (nervous system), Category 3 (respiratory tract irritation) Danger
Warning 		H370: Causes damage to organs (systemic toxicity)
H371: May cause damage to organs (nervous system)
H335: May cause respiratory irritation (respiratory tract irritation) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the human evidence: "Ingestion of 0.5L of a solution of ziram of unknown concentration was fatal within a few hours; nonspecific pathology was observed" (IARC 53 (1991)), "findings included focal necrosis of the mucosa of the small intestine, congestion and microscopic edema of many organs, diapedetic hemorrhages, focal atelectases, acute emphysema, and desquamation of alveolar and bronchial epithelium. The pathology was nonspecific" (HSDB (2003)), and "irritating to the respiratory tract" (ICSC (J) (2000)). Also based on the evidence from animal studies including "somnolency, and changes in physical capabilities" (IUCRID (2000)).
9 Specific target organ toxicity - Repeated exposure Category 1 (liver), Category 2 (blood system, adrenal gland, nervous system, kidney, muscle, urinary bladder) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (liver)
H373: May cause damage to organs through prolonged or repeated exposure (blood system, adrenal gland, nervous system, kidney, muscle, urinary bladder) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "may adversely affect the central nervous system" (IPCS (J) (2000)). Also based on the evidence from animal studies including "decreases in RBC, PCV and hemoglobin, and an increase in reticulocyte count," "centrilobular fibrocytes were seen" (JMPR Ziram (Pesticide residues in food 1996 evaluations Part II Toxicological)), "adrenal cortical hypertrophy/degeneration/vacuolation increased; there was an increase in sciatic nerve axonal degeneration and lipofuscin in tubular kidney epithelium; increased adipose replacement and narrowing of peripheral muscle fiber bundles occurred in skeletal muscle; bile duct hyperplasia and pigmented sinusoidal cell incidence increased," "urinary bladder epithelial hyperplasia was increased" (HSDB 2003). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (liver) and Category 2 (blood system, adrenal, nervous system, kidneys, muscles, bladder).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 48 hours LC50=0.14mg/L of the crustacea (Daphnia magna) (EHC78, 2001).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=1.23(PHYSPROP Database, 2005)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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