Chemical Name：N,N'-ethylenebis(thiocarbamoylthiozinc) bis(N,N-dimethyldithiocarbamate)
CAS：64440-88-6

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 1,761mg/kg (Agricultural Chemical Registration Data (1993)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >2,000mg/kg, together with the absence of mortality (Agricultural Chemical Registration Data (1993)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the rat LC50 (inhalation route) value of 0.104mg/L (4 hours) (Agricultural Chemical Registration Data (1986)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on the evidence of mild irritation with a Draize score of ca.1.3, which was fully reversed within 7 days, observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1986)).
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Based on the evidence of severe irritation which persisted for at least 7 days of observation in rabbit eye irritation tests (Agricultural Chemical Registration Data (1986)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1986)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro chromosome aberration tests (Agricultural Chemical Registration Data (1986)), in vivo micronucleus tests on rat bone marrow cells (Agricultural Chemical Registration Data (1996)), though in vitro reverse mutation tests showed positive (Agricultural Chemical Registration Data (1993)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1986)). Also due to the fact that the substance is classified as Category 3 by IARC (1987).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1988, 1993)).
8	Specific target organ toxicity - Single exposure	Category 2 (central nervous system), Category 3 (respiratory tract irritation)		Warning	H371: May cause damage to organs (central nervous system) H335: May cause respiratory irritation (respiratory tract irritation)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell.	In single dose oral toxicity studies in mice, clinical signs including soft feces, reduced locomotor activity and crouching were noted at dose levels within the guidance value ranges for Category 2, whereas in single dose inhalation toxicity studies in rats, clinical signs including abnormal respiratory sounds, lacrimation and inanimation were seen at dose levels within the guidance value ranges for Category 1.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	There were effects on the blood system, but the exposure doses exceeded the guidance value ranges for Category 2 by a factor of 1.5.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96 hours LC50=0.91mg/L of the fish (Carp) (Agricultural Chemical Registration Data, 2003).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and rapidly degrading and bio-accumulation were unknown, it was classified into Category 1.