GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Arsenic acid
CAS：7778-39-4
Result：
| ID: | 466 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable (Aqueous solution) | - | - | - | - | Containing no chemical groups with explosive properties |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable (Aqueous solution) | - | - | - | - | Classified as "liquid" according to GHS definition (aqueous solution) |
| 3 | Aerosols | Not applicable (Aqueous solution) | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable (Aqueous solution) | - | - | - | - | Classified as "liquid" according to GHS definition (aqueous solution) |
| 5 | Gases under pressure | Not applicable (Aqueous solution) | - | - | - | - | Classified as "liquid" according to GHS definition (aqueous solution) |
| 6 | Flammable liquids | Not classified (Aqueous solution) | - | - | - | - | Arsenic acid 0.5 hydrate is classified as non-flammable (HSDB (2006)) |
| 7 | Flammable solids | Not applicable (Aqueous solution) | - | - | - | - | Classified as "liquid" according to GHS definition (aqueous solution) |
| 8 | Self-reactive substances and mixtures | Not applicable (Aqueous solution) | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
| 9 | Pyrophoric liquids | Not classified (Aqueous solution) | - | - | - | - | Arsenic acid 0.5 hydrate is classified as non-flammable (HSDB (2006)) |
| 10 | Pyrophoric solids | Not applicable (Aqueous solution) | - | - | - | - | Classified as "liquid" according to GHS definition (aqueous solution) |
| 11 | Self-heating substances and mixtures | Classification not possible (Aqueous solution) | - | - | - | - | Arsenic acid is present only in aqueous solutions. Test methods applicable to liquid substances are not available. |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified (Aqueous solution) | - | - | - | - | Stable to water (arsenic acid is present only in aqueous solutions (Lide, 84th, 2003)). |
| 13 | Oxidizing liquids | Not classified (Aqueous solution) | - | - | - | - | Inorganic compounds containing oxygen and classified as powerful oxidants (80% aqueous solution) (ICSC (2004)). Classified into Division 6.1 (UN#1553 (solution)) (UN Recommendations on the Transport of Dangerous Goods). |
| 14 | Oxidizing solids | Not applicable (Aqueous solution) | - | - | - | - | Classified as "liquid" according to GHS definition (aqueous solution) |
| 15 | Organic peroxides | Not applicable (Aqueous solution) | - | - | - | - | Not organic compounds |
| 16 | Corrosive to metals | Not classified (Aqueous solution) | - | - | - | - | Classified into Division 6.1 (UN#1553 (solution)) (UN Recommendations on the Transport of Dangerous Goods). |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 48mg/kg (RTECS (2006)). |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected. |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2" and "ID55, Diarsenic Trioxide (Arsenous Acid), CAS: 1327-53-3." |
| 6 | Carcinogenicity | Category 1A |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as Category K (Arsenic Compounds, Inorganic) by NTP (2005), Group 1 (ARSENIC AND ARSENIC COMPOUNDS) by IARC (1987), Category A1 (Arsenic and inorganic compounds) by ACGIH (2001) and Category 1 (as arsenic and arsenic compounds (As)) by the Japan Society for Occupational Health. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of an increased incidence of resorptions and a reduction in fetal body weight at doses producing maternal toxicity in oral studies, described in EHC 224 (2001). As for the health hazards, refer to "ID1075, Sodium Arsenate, CAS: 13464-38-5," "ID1088, Sodium Arsenite, CAS: 7784-46-5," "ID54, Arsenic, CAS: 7440-38-2," "ID55, Diarsenic Trioxide (Arsenous Acid), CAS: 1327-53-3." |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (gastrointestinal tract, circulatory system, nervous system, blood system, respiratory system, skin, kidney, bone marrow, liver) |
|
Danger | H370: Causes damage to organs (gastrointestinal tract, circulatory system, nervous system, blood system, respiratory system, skin, kidney, bone marrow, liver) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "acute toxicity of arsenic compounds manifests in humans as symptoms in the gastrointestinal tract and cardiovascular/nervous/blood systems, conjunctivitis and dermatitis along with nasal mucosal/pharyngeal/respiratory irritation, pollakiuria or anuria due to renal tubular blockage by hemoglobin coagulation" (IARC 84 (2004)) and "bone-marrow failure and hepatic hypertrophy" (EHC 224 (2001)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system, skin, liver, cardiovascular system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, skin, liver, cardiovascular system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "upper respiratory symptoms such as nasal catarrh, pharyngitis and nasal septum perforation," "respiratory disorder following exposure via drinking water," "pigmentation and keratosis," "cirrhosis," "cardiovascular abnormalities" and "peripheral vascular disorder" (IARC 84 (2004)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 96 hours LC50=2.0ppm of the crustacea (Mysid Shrimp)) (AQUIRE, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Category 2 |
|
- | H411: Toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 2 and it was a metallic compound and an underwater action and bio-accumulation were unknown, it was classified into Category 2. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |