GHS Classification Result

Chemical Name：Piperazine
CAS：110-85-0

Result：
ID: 469
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - Classified as flammable according to ICSC (2003). Classified into Class 8 (UN#2579) (UN Recommendations on the Transport of Dangerous Goods).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 320degC (ICSC, 2003).
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available (melting point: 106degC (ICSC, 2003), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine and chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 1,280mg/kg calculated from the testing data of rat LD50 (oral route) of 600mg/kg, 11,200mg/kg (CERI Hazard Data 2001-13 (2002)), 2,830mg/kg (CERI-NITE Hazard Assessment No.19 (2005)), 2,600mg/kg (EU-RAR No.56 (2005)), 2,050mg/kg, 3,000mg/kg (PATTY (4th, 2000)) and 1,900mg/kg (DFGOT vol.9 (1998)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 1,590mg/kg representing the lower of the two testing data, 4,000mg/kg (CERI Hazard Data 2001-13 (2002)) and 1,590mg/kg (CERI-NITE Hazard Assessment No.19 (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rabbit skin irritation tests (4 hour application) (CERI-NITE Hazard Assessment No.19 (2005), EU-RAR No.56 (2005) and DFGOT vol.9 (1998)): Severe irritation with irreversible effects, indicative of corrosivity. Although classified as Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 2001-13 (2002), CERI-NITE Hazard Assessment No.19 (2005), PATTY (4th, 2000) and DFGOT vol.9 (1998)): "strong irritation," "severe corneal opacity" and "serious eye damage which is unlikely to heal." The substance is thus considered to possess a potential for corrosivity.
4 Respiratory sensitization Category 1 Danger H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P285: In case of inadequate ventilation wear respiratory protection.
P501: Dispose of contents/container to ... 		Based on the description of the human health effects (CERI Hazard Data 2001-13 (2002), EU-RAR No.56 (2005) and PATTY (4th, 2000)): Piperazine induced symptoms of respiratory sensitization such as asthma. Also due to the fact that the substance is classified as a "Respiratory Sensitizing Substance" by the Japanese Society of Occupational Allergy.
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the descriptions of the human health effects (CERI Hazard Data 2001-13 (2002), EU-RAR No.56 (2005), CERI-NITE Hazard Assessment No.19 (2005) and PATTY (4th, 2000)): the substance showed "positive" in patch tests. Also due to the fact that the substance is classified as a "Skin Sensitizing Substance" by the Japanese Society of Occupational Allergy.
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on multi-generation mutagenicity tests, germ/somatic cell mutagenicity tests in vivo and germ/somatic cell genotoxicity tests in vivo, and no positive data on mutagenicity tests in vitro (several indices), described in CERI-NITE Hazard Assessment No.19 (2005), NITE Initial Risk Assessment No.19 (2005) and NTP DB (Access on March 2006).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on expert judgment in the absence of existing classification.
7 Reproductive toxicity Classification not possible - - - - Insufficient data available
8 Specific target organ toxicity - Single exposure Category 2 (nervous system, respiratory system) Warning H371: May cause damage to organs (nervous system, respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the human evidence including "somnolency, nausea or vomiting" (RTECS (2004)), "corrosive to the eye, skin and respiratory tract; adversely affects the nervous system; ingestion of large doses may cause functional impairment of the organs involved and can result in loss of consciousness" (ICSC (J) (2003)).
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system, respiratory system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system, respiratory system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence including "headache , nausea, vomiting, diarrhea, lethargy, tremor, incoordination and muscle weakness" (CERI Hazard Data 2001-13 (2002)), and "chronic bronchitis" (CERI-NITE Hazard Assessment No.19 (2005)).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 48 hours EC50=21mg/L of the crustacea (Daphnia magna) (EU-RAR, 2004).
11 Hazardous to the aquatic environment （Long-term） Not classified - - - - Although the acute toxicity was Category 3, judging from the NOEC=12.5mg/L during 21 days of the crustacea (Daphnia magna) (EU-RAR, 2004), it was classified into Not classified.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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