Chemical Name：butyl (R)-2-[4-(4-cyano-2-fluorophenoxy)phenoxy]propionate
CAS：122008-85-9

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1995)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rabbit LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1995)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on the rat LC50 (inhalation route) value of >5.0mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data (1995)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	In rabbit skin irritation tests, mild irritation was noted immediately after the application with a score of 0.2, but the effects cleared up by 24 hours (Agricultural Chemical Registration Data (1995)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	In rabbit eye irritation tests, mild irritation was noted immediately after instillation with a score of 0.2, but the effects cleared up by 24 hours (Agricultural Chemical Registration Data (1995)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1995)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro reverse mutation tests, in vitro chromosome aberration tests (Agricultural Chemical Registration Data (1995)) and in vivo micronucleus tests on mouse bone marrow cells (Agricultural Chemical Registration Data (1995)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1995)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1995)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "increased weights of liver and kidneys, and hepatocellular swelling," "darkening of the liver," "liver swelling," and "hepatocellular swelling" (Agricultural Chemical Registration Data (1995)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since a potential that relevant toxicity was discovered in the water solubility (0.44mg/L(HSDB, 2004)) of this substance cannot be denied from 96-hour LC50=1.13mg/L of the fish (Carp) (Agricultural Chemical Registration Data, 1995), it was classified into Category 1.
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and rapidly degrading and bio-accumulation were unknown, it was classified into Category 1.