GHS Classification Result

Chemical Name:hexakis(2-methyl-2-phenylpropyl)distannoxane
CAS:13356-08-6

Result:
ID: 483
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Classification not possible - - - - Classification not possible due to lack of data
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is stable to heat (up to 280degC) (Agricultural Chemical Registration Data)
11 Self-heating substances and mixtures Not classified - - - - Stable to heat (up to 280degC) (Agricultural Chemical Registration Data)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 15.78*10^(-6)g/L (20degC) (Agricultural Chemical Registration Data))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 140-145degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1979)).
1 Acute toxicity (Dermal) Not classified - - - - Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1979)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >1.83mg/L (4 hours) (Agricultural Chemical Registration Data (1987)).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P362: Take off contaminated clothing and wash before reuse.
Based on the description in the report on skin irritation tests in mammals (species unknown) (HSDB (2006)): "Irritating" (though exposure duration and severity of the effects are not presented).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
Based on the description in the report on eye irritation tests in mammals (species unknown) (HSDB (2006)): "Severely irritating."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (2004)).
5 Germ cell mutagenicity Not classified - - - - Based on negative data in in vitro chromosome aberration tests, in vitro gene mutation tests in bacteria and yeast, mouse in vivo micronucleus tests, in vivo chromosome aberration tests and in vivo dominant lethal tests (Agricultural Chemical Registration Data (1979, 2004, 2005)).
6 Carcinogenicity Not classified - - - - There was no treatment-related increase in tumor incidence observed in rat and mouse carcinogenicity studies (Agricultural Chemical Registration Data (1979)). Also due to the fact that the substance is classified as Category A4 by ACGIH (2006).
7 Reproductive toxicity Not classified - - - - Based on no evidence of adverse effects on reproduction or offspring development observed in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1979, 1987)).
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, kidney), Category 2 (liver, testis) Danger
Warning
H370: Causes damage to organs (respiratory system, kidney)
H371: May cause damage to organs (liver, testis)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
Based on the evidence from animal studies: "Inhalation exposure produced necrosis of bronchiolar epithelium, lung congestion and edema, and lesions in renal tubule epithelium" (JMPR (1992)), "massive fatty changes in the liver, reduced spermatogenesis" (JMPR (1977)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96 hours LC50=2.0microg/L of the fish (Carp) (Agricultural Chemical Registration Data, 2004).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.2 (PHYSPROP Database, 2005)), it was classified into Category 1.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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