GHS Classification Result

Chemical Name:Beryllium sulfate, Tetrahydrate
CAS:7787-56-6

Result:
ID: 487
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Classified as "solid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "solid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "solid" according to GHS definition
6 Flammable liquids Not applicable - - - - Classified as "solid" according to GHS definition
7 Flammable solids Not classified - - - - The anhydride of beryllium sulfate is classified as non-flammable by HSDB (2006)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though being sulfonyls, containing chemical groups with self-reactive properties
9 Pyrophoric liquids Not applicable - - - - Classified as "solid" according to GHS definition
10 Pyrophoric solids Not classified - - - - The anhydride of beryllium sulfate is classified as non-flammable by HSDB (2006)
11 Self-heating substances and mixtures Not classified - - - - The anhydride of beryllium sulfate is classified as non-flammable by HSDB (2006)
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 41.3g/100g (anhydride equivalent, 25degC), Lide (84th, 2003))
13 Oxidizing liquids Not applicable - - - - Classified as "solid" according to GHS definition
14 Oxidizing solids Classification not possible - - - - Classification not possible due to lack of data, though being inorganic compounds containing oxygen
15 Organic peroxides Not applicable - - - - Not organic compounds
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 3 Danger H301: Toxic if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LD50 value of 140 mg BeSO4.4H2O/kg calculated from the testing data of rat LD50 (oral route) of 7.0 mg beryllium/kg (DFGOT Vol.21 (2005)).
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the LC50 value of 0.029 mg BeSO4.4H2O/L calculated from the testing data of rat LC50 (4 hour inhalation) of 0.15 mg beryllium/m3 (DFGOT Vol.21 (2005)).
2 Skin corrosion/irritation Classification not possible - - - - No data available
3 Serious eye damage/eye irritation Classification not possible - - - - No data available
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Category 1 Warning H317: May cause an allergic skin reaction P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
Based on the positive results in patch tests and Maximization Tests reported in human epidemiological studies (DFGOT Vol.21 (2005)), and the positive results in guinea pig skin sensitization tests carried out according to Maximization Method. The substance is thus considered a sensitizing skin irritant.
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in NTP DB (Access on May, 2006), IARC 58 (1993), ATSDR (2002) and DFGOT Vol.21 (2005).
6 Carcinogenicity Category 1A Danger H350: May cause cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Due to the fact that the substance is classified as Category K (Beryllium (CAS 7440-41-7) and Beryllium Compounds) by NTP (2005) and Category 1 (BERYLLIUM AND BERYLLIUM COMPOUNDS) by IARC (1993).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence of abnormal behaviour of the offspring such as delayed response in head turning in a geotaxis test and delayed bar-holding response following intraperitoneal injection of the substance (140ng Be/mouse per day), described in EHC 106 (1990) (though no data are available on maternal toxicity). As for the reproductive toxicity of beryllium compounds, refer to "ID485, Beryllium Oxide, CAS: 1304-56-9."
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system) Danger H370: Causes damage to organs (respiratory system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the evidence from animal studies: "occurrence of pneumonitis with thickening of the alveolar walls and inflammation of the lung" in rats and mice (ATSDR (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, blood system) Danger H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, blood system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
Based on the human evidence: "field studies were carried out, and it became evident that the acute respiratory effects could be caused by inhalation of beryllium fluoride, sulfate, chloride, oxide, or hydroxide, and metallic dust" (EHC 106 (1990)). Also based on the evidence from animal studies including "inflammation, emphysema, and fibrosis of the lung were observed. Histological examination revealed glomerular degeneration in the kidneys," "the lung appeared to be severely inflamed and emphysematous; leukocytosis and thrombocytosis were observed," "inflammation and fibrosis of the lung" (ATSDR (2002)), "chronic pneumonia; localized granulomatous lesions" (EHC 106 (1990)) The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ...
It was classified into Category 2 from 96 hours 0.15-0.2mg Be/L(Beryllium Sulfate Equivalent=1.75-2.34mg/L) of the fish (Fathead Minnows) (EHC106, 1990).
11 Hazardous to the aquatic environment (Long-term) Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Although acute toxicity was Category 2 and bio-accumulation was low (BCF=230 (Existing Chemical Safety Inspections Data)), since it was a metallic compound and the underwater action was unknown, it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

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Model SDS by MHLW

MHLW Website (in Japanese Only)


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