Chemical Name:Boric acid
CAS:10043-35-3
ID: | 491 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Not classified | - | - | - | - | Non-flammable (ICSC,1999) |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Non-flammable (ICSC,1999) |
11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-flammable (ICSC,1999) |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Stable to water (water solubility: 5.80g/100g (25degC), Lide (84th, 2003)) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data, though being inorganic compounds containing oxygen |
15 | Organic peroxides | Not applicable | - | - | - | - | Not organic compounds |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Category 5 | - | Warning | H303: May be harmful if swallowed | P312: Call a POISON CENTER or doctor/physician if you feel unwell. | Based on the LD50 value of 3,241mg/kg calculated from the testing data of rat LD50 (oral route) of 2,660mg/kg, 5,140mg/kg, 3,160mg/kg, 3,450mg/kg, 4,080mg/kg and 5,000mg/kg (DFGOT vol.5 (1993)). |
1 | Acute toxicity (Dermal) | Classification not possible | - | - | - | - | Insufficient data available |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | Insufficient data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Classification not possible | - | - | - | - | Insufficient data available |
2 | Skin corrosion/irritation | Category 2 | Warning | H315: Causes skin irritation |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P362: Take off contaminated clothing and wash before reuse. |
Based on the description in the report on guinea pig skin irritation tests (exposure duration unknown) (CERI Hazard Data 2001-30 (2002)): "At 24 and 72 hours, moderate irritation was noted." | |
3 | Serious eye damage/eye irritation | Category 2A-2B | Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on the description of the human health effects (ATSDR (1992) and ACGIH (7th, 2005)): The substance irritates the human eye (though the severity of the effects and recovery period are not presented). Although classified into Category 2A-2B, it should be placed in Category 2A from the viewpoint of safety if further subclassification is needed. | |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on the absence of data on multi-generation mutagenicity tests and germ cell mutagenicity tests in vivo, and negative data on somatic cell mutagenicity tests in vivo (micronucleus tests), described in NTP DB (Access on Apr., 2006), ECETOC TR63 (1995), CERI Hazard Data 2001-42 (2002) and ACGIH (7th, 2005). |
6 | Carcinogenicity | Not classified | - | - | - | - | Due to the fact that the substance is classified as Category A4 (as inorganic borate compounds) by ACGIH (2005). |
7 | Reproductive toxicity | Category 1B | Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of adverse effects on reproduction of parental animals and development of pups at doses producing no parental toxicity, described in NTP DB (Access on May, 2006), CERI Hazard Data 2001-30 (2002). | |
8 | Specific target organ toxicity - Single exposure | Category 1 (nervous system, gastrointestinal tract), Category 3 (respiratory tract irritation) |
Danger Warning |
H370: Causes damage to organs (nervous system, gastrointestinal tract) H335: May cause respiratory irritation (respiratory tract irritation) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the human evidence including "GI effects such as nausea, vomiting, abdominal pain and diarrhea, and central nerve effects such as lethargy, headaches, fever, increased irritability and muscle convulsion" (CERI Hazard Data 2001-30 (2002)), "irritation of the upper respiratory tract" (ATSDR (1992)), and the evidence from animal studies including "cyanosis, tetany, spasm and shock-like symptoms" (CERI Hazard Data 2001-30 (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence including "oliguresis, anuria, and nephropathy including renal tubular necrosis" (CERI Hazard Data 2001-30 (2002)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Not classified | - | - | - | - | It was classified into Not classified from 96 hours LC50=78.1mg boron/L(Boric Acid Equivalent: 447mg/L) of the fish (Rainbow Trout) (EHC204, 1998). |
11 | Hazardous to the aquatic environment (Long-term) | Not classified | - | - | - | - | Since it was not water-insolubility (the water-solubility =50000mg/L (PHYSPROP Database, 2005)), and acute toxicity was low, it was classified into Not classified. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |