GHS Classification Result

Chemical Name：Poly(oxyethylene) alkyl ether (alkyl C=12-15)
CAS：

Result：
ID: 492
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10))
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).
6 Flammable liquids Not classified (Poly (oxyethylene) dodecyl ether) - - - - The flash point is >93degC (c.c.) (NFPA (2002)) (poly(oxyethylene)dodecyl ether (the number of ethylene oxide units unknown)).
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Considered non-pyrophoric when in contact with air at ordinary temperatures since the substance is used as laundry detergents (CERI-NITE Hazard Assessment (2006))
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).
11 Self-heating substances and mixtures Classification not possible - - - - Test method applicable to liquid substances are not available (solidification point: 16degC (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added, HSDB (2006)), test temperature: 140degC).
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen (but not fluorine and chlorine), with oxygen bound to carbon and hydrogen (but not to other elements)
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition (poly(oxyethylene)dodecyl ether, when 10 moles of ethylene oxide added (EO10)).
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 544mg/kg representing the lower of the two testing data, 544mg/kg (alkyl C14-15, EO11) and 9,800mg/kg (alkyl C10,12,14, EO2-7) (CERI-NITE Hazard Assessment No.89 (2005)).
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on the rabbit LD50 (dermal route) value of 2,000mg/kg representing the lower of the two testing data, 2,000mg/kg (alkyl C12-13, EO6) and 5,000mg/kg (alkyl C14-15, EO13) (CERI-NITE Hazard Assessment No.89 (2005)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is a liquid according to the GHS criteria and inhalation of its gas is not expected..
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Category 4 Warning H332: Harmful if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the rat LC50 (inhalation route) value of 1.5mg/L (alkyl C12-13, EO6) (4 hours).
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		Based on the description in the report on rabbit skin irritation tests (CERI-NITE Hazard Assessment No.89 (2005)): "Two undiluted test materials with different chain lengths (Alkyl C12-13, EO chain length unknown; C12-15, EO chain length unknown) produced moderate to severe irritation when applied for 24 (not 4) hours."
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (CERI-NITE Hazard Assessment No.89 (2005)): "Two test materials with different chain lengths (Alkyl C12-13, EO6; C14-15, EO7) produced severe irritation when applied neat. The reactions persisted for at least 35 days." Both materials are "very strongly irritating, with effects not resolving within 21 days," and thus considered to be "irreversible."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - Insufficient data available
5 Germ cell mutagenicity Not classified - - - - Based on the absence of data on multi-generation mutagenicity tests and in vivo germ cell mutagenicity tests, and negative data in in vivo somatic cell mutagenicity tests (chromosome aberration tests and micronucleus tests), described in CERI-NITE Hazard Assessment No.89 (2005).
6 Carcinogenicity Classification not possible - - - - Classification not possible based on a judgment made by experts in the absence of existing classification, though CERI-NITE Hazard Assessment No.89 (2005) presents some toxicity data.
7 Reproductive toxicity Not classified - - - - Based on no evidence of reproductive effects observed in rat reproductive toxicity studies and teratogenicity studies, described in CERI-NITE Hazard Assessment No.89 (2005).
8 Specific target organ toxicity - Single exposure Category 3 （Narcotic effects） Warning H336: May cause drowsiness or dizziness (narcotic effects) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "somnolency, increased mobility," and "ataxia" (RTECS 2006).
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - Insufficient data available
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 (C14AE1, C14-15AE7), Category 2 (C12-15AE12) Warning H400: Very toxic to aquatic life (C14AE1, C14-15AE7)
H401: Toxic to aquatic life (C12-15AE12) 		P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		C14AE1: It was classified into Category 1 from 48 hours EC50=0.14mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005)). C14-15AE7: It was classified into Category 1 from 48 hours LC50=0.62mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005)). C12-15AE12: It was classified into Category 2 from 48 hours EC50=1.4mg/L of the crustacea (Daphnia magna) (CERI/NITE Hazard Assessment Report (2005)). [NOTE] Since the toxicity of polyoxyethylene alkyl ether increases as ethylene oxide chain length decreases, it pointed to the category of several ethylene oxide chain length. In addition, polyoxyethylene alkyl ether described as CmAEn (m: alkyl carbon numbers, n: mole numbers of added ethylene oxide.).
11 Hazardous to the aquatic environment （Long-term） Category 1 (C14-15AE7), Classification not possible (C14AE1, C12-15AE12) Warning H410: Very toxic to aquatic life with long lasting effects (C14-15AE7) P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		C14-15AE7: Although the acute toxicity was Category 1 and it had potential to rapidly degrade (the decomposition by BOD(C12AE40): 74% (CERI/NITE Hazard Assessment Report (2005))), since it had potential to bioaccumulate (BCF=700-800(C14AE7) (CERI/NITE Hazard Assessment Report (2005))), it was classified into Category 1. C14AE1, C12-15AE12: Although it had potential to rapidly degrade (the decomposition by BOD(C12AE40): 74% (CERI/NITE Hazard Assessment Report (2005))), since there was no data about bioaccumulation of each component (as the bioaccumulation depends on alkyl carbon numbers and mole numbers of added ethylene oxide), classification is not possible. [NOTE] Since the toxicity of polyoxyethylene alkyl ether increases as ethylene oxide chain length decreases, it pointed to the category of several ethylene oxide chain length. In addition, polyoxyethylene alkyl ether described as CmAEn (m: alkyl carbon numbers, n: mole numbers of added ethylene oxide.).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
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