Chemical Name:O-3-tert-butylphenyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate
CAS:88678-67-5
ID: | 510 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test method applicable to liquid substances are not available (melting point: 86.3-88.2degC (Agricultural Chemical Registration Data), test temperature: 140degC). |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 86.3-88.2degC (Agricultural Chemical Registration Data)). |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Acute toxicity (Oral) | Not classified | - | - | - | - | Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1988)). |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1988)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Not classified | - | - | - | - | Based on the rat LC50 (inhalation route) value of >6.52mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data (1988)). |
2 | Skin corrosion/irritation | Not classified | - | - | - | - | Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1988)). |
3 | Serious eye damage/eye irritation | Not classified | - | - | - | - | Based on the evidence of conjunctival injection with a score of 1 at 1 hour after instillation; 0.2 at 24 hours; the effects cleared up by 72 hours in all affected animals (Agricultural Chemical Registration Data (1988)). |
4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
4 | Skin sensitization | Not classified | - | - | - | - | No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1988)). |
5 | Germ cell mutagenicity | Not classified | - | - | - | - | Based on negative data in in vitro assays (reverse mutation tests, chromosome aberration tests and DNA repair tests) and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1988, 2004)). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Based on a judgment made by experts in the absence of existing classification, though some data are available on carcinogenicity studies in rats and mice. |
7 | Reproductive toxicity | Not classified | - | - | - | - | Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1988)). |
8 | Specific target organ toxicity - Single exposure | Classification not possible | - | - | - | - | Insufficient data available In a rat inhalation study, one test animal exhibited accumulation of whitish foamy fluid in the trachea, and dark reddening and edematous changes of the lung. |
9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | Insufficient data available |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 72 hours EbC50=0.0977mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.18 (PHYSPROP Database, 2005)), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |