NITE - Chemical Management Field

GHS Classification Result

Chemical Name：O-3-tert-butylphenyl N-(6-methoxy-2-pyridyl)-N-methylthiocarbamate
CAS：88678-67-5

Result：


ID:	510
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	Containing no chemical groups with explosive properties
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
5	Gases under pressure	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
6	Flammable liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
7	Flammable solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data
8	Self-reactive substances and mixtures	Not applicable	-	-	-	-	Containing no chemical groups with explosive or self-reactive properties
9	Pyrophoric liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
10	Pyrophoric solids	Classification not possible	-	-	-	-	Classification not possible due to lack of data
11	Self-heating substances and mixtures	Classification not possible	-	-	-	-	Test method applicable to liquid substances are not available (melting point: 86.3-88.2degC (Agricultural Chemical Registration Data), test temperature: 140degC).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13	Oxidizing liquids	Not applicable	-	-	-	-	Classified as "solid" according to GHS definition
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no "-O-O-" structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances with melting point of >55degC are not available (melting point: 86.3-88.2degC (Agricultural Chemical Registration Data)).

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Not classified	-	-	-	-	Based on the rat LD50 (oral route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1988)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1988)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Not classified	-	-	-	-	Based on the rat LC50 (inhalation route) value of >6.52mg/L (4 hours), together with the absence of mortality (Agricultural Chemical Registration Data (1988)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1988)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the evidence of conjunctival injection with a score of 1 at 1 hour after instillation; 0.2 at 24 hours; the effects cleared up by 72 hours in all affected animals (Agricultural Chemical Registration Data (1988)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests employing the Maximization method (Agricultural Chemical Registration Data (1988)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro assays (reverse mutation tests, chromosome aberration tests and DNA repair tests) and mouse in vivo micronucleus tests (Agricultural Chemical Registration Data (1988, 2004)).
6	Carcinogenicity	Classification not possible	-	-	-	-	Based on a judgment made by experts in the absence of existing classification, though some data are available on carcinogenicity studies in rats and mice.
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat 2-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1988)).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	Insufficient data available In a rat inhalation study, one test animal exhibited accumulation of whitish foamy fluid in the trachea, and dark reddening and edematous changes of the lung.
9	Specific target organ toxicity - Repeated exposure	Classification not possible	-	-	-	-	Insufficient data available
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 72 hours EbC50=0.0977mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 1 and there was no rapidly degrading (BIOWIN), and since there wasbio-accumulation (log Kow=5.18 (PHYSPROP Database, 2005)), it was classified into Category 1.

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）