GHS Classification Result

Chemical Name：Tris(2-chloroethyl) phosphate
CAS：115-96-8

Result：
ID: 512
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 216degC (open cup flash test) (Sax (11th, 2004))
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures: the auto-ignition temperature is 602degC (Sax, 11th, 2004).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Stable to water (water solubility: 5g/L (20degC), BUA20 (1987))
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data, though being organic compounds containing oxygen bound to elements other than carbon and hydrogen
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the LD50 value of 542mg/kg calculated from the testing data of rat LD50 (oral route) of 200mg/kg (CERI Hazard Data 98-22 (1999)), 501mg/kg, 430mg/kg, 794mg/kg, 1,230mg/kg, 1,410mg/kg, 1,150mg/kg and 3,600mg/kg (CERI-NITE Hazard Assessment No.205 (2004)).
1 Acute toxicity （Dermal） Not classified - - - - Based on the rabbit LD50 (dermal route) value of > 28,500mg/kg (CERI Hazard Data 98-22 (1999)).
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - Insufficient data available
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. Based on the description in the report on rabbit skin irritation tests (CERI Hazard Data 98-22 (1999) and CERI-NITE Hazard Assessment No.205 (2004)): "mild irritation," "mild erythema."
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling. 		Based on the description in the report on rabbit eye irritation tests (CERI Hazard Data 98-22 (1999)): "Mildly irritating."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - "No evidence of skin sensitization" was obtained in Buehler Tests on guinea pigs (CERI-NITE Hazard Assessment No.205 (2004)). However, classification is not possible, with only one set of data showing "negative" available.
5 Germ cell mutagenicity Category 1B Danger H340: May cause genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on positive data on multi-generation mutagenicity tests (dominant lethal tests), described in IARC 71 (1999), CERI-NITE Hazard Assessment No.205 (2004), NTP DB (Access on May 2006) and EHC 209 (1998).
6 Carcinogenicity Not classified - - - - Due to the fact that the substance is classified as Group 3 by IARC (1999).
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence of decreased numbers of live fetuses per litter and testicular effects at parental toxic doses (or in the absence of data on general toxicity) in rat teratogenicity studies and continuous breeding studies, described in MOE Risk Assessment vol. 1 (2002) and EHC 209 (1998).
8 Specific target organ toxicity - Single exposure Category 1 (nervous system), Category 3 (narcotic effects) Danger
Warning 		H370: Causes damage to organs (nervous system)
H336: May cause drowsiness or dizziness (narcotic effects) 		P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell. 		Based on the evidence from animal studies including "piloerection and salivation, hunchback position (in all treated animals), abnormal gait, lethargy, labored respiration, blepharoptosis and paleness of extremities," "dose-dependent increase in rearing and tremor (wet dog shakes)" (CERI-NITE Hazard Assessment No.205 (2004)), "(treated animals) convulsed within 60-90 hours and had extensive loss of CA1 hippocampal pyramidal cells when examined after 7 days, suggesting long-term impairment of some brain functions" (EHC 209 (1998)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system), Category 2 (kidney) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (nervous system)
H373: May cause damage to organs through prolonged or repeated exposure (kidney) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the human evidence: "Clinical signs included weakness in arms and abdominal muscles and abnormalities in electromyogram and nerve conduction velocities" (NICNAS (2001)). Also based on the evidence from animal studies including "dose-dependent increase in the incidence of hyperplasia of the renal tubular epithelium (renal cortex convoluted tubules); degeneration and necrosis of neurocytes in the brain stem and cerebrum, reactive gliosis, hemorrhage, mineral deposition, pigmentation or hemosiderin deposition, local lesions in the cerebrum and thalamus" (CERI-NITE Hazard Assessment No.205 (2004)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 2.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 3 - - H402: Harmful to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 3 from 96 hours LC50=90mg/L of the fish (Goldfish) (CERI/NITE Hazard Assessment Report, 2004).
11 Hazardous to the aquatic environment （Long-term） Category 3 - - H412: Harmful to aquatic life with long lasting effects P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 3 and the bio-accumulation potential was low (BCF=5.1(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 4%(Existing Chemical Safety Inspections Data)), it was classified into Category 3.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information