Chemical Name:p-Aminophenol
CAS:123-30-8
ID: | 515 |
Classifier: | Inter-ministerial Committee on GHS |
Year Classified: | FY2006 |
Reference Manual: | GHS Classification Manual (10 Feb, 2006) |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
1 | Explosives | Not applicable | - | - | - | - | Containing no chemical groups with explosive properties |
2 | Flammable gases (including chemically unstable gases) | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
4 | Oxidizing gases | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
5 | Gases under pressure | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
6 | Flammable liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
7 | Flammable solids | Classification not possible | - | - | - | - | Classified as flammable according to HSDB (2006). Classified into Division 6.1 (UN#2261 (o-, m-, p-)) (UN Recommendation on the Transport of Dangerous Goods). |
8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Containing no chemical groups with explosive or self-reactive properties |
9 | Pyrophoric liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
10 | Pyrophoric solids | Not classified | - | - | - | - | Although classified as flammable, the substance does not catch fire easily (HSDB, 2006). Classified into Division 6.1 (UN#2512 (o-, m-, p-)) (UN Recommendations on the Transport of Dangerous Goods). |
11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | No data available |
12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At) |
13 | Oxidizing liquids | Not applicable | - | - | - | - | Classified as "solid" according to GHS definition |
14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not fluorine and chlorine), with the oxygen bound to carbon and hydrogen (but not to other elements) |
15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no "-O-O-" structure |
16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
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1 | Acute toxicity (Oral) | Category 4 | Warning | H302: Harmful if swallowed |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
Based on the rat LD50 (oral route) value of 375mg/kg (RTECS (2006)). | |
1 | Acute toxicity (Dermal) | Not classified | - | - | - | - | Based on the rabbit LD50 (oral route) value of > 8,000mg/kg representing the lower of the two testing data, > 8,000mg/kg (IUCLID (2000)) and > 16,000mg/kg (RTECS (2006)). |
1 | Acute toxicity (Inhalation: Gases) | Not applicable | - | - | - | - | Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected. |
1 | Acute toxicity (Inhalation: Vapours) | Classification not possible | - | - | - | - | No data available |
1 | Acute toxicity (Inhalation: Dusts and mists) | Category 4 | Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
Based on the rat LC50 (inhalation of dust/mist) value of 1.48mg/L (IUCLID (2000)). | |
2 | Skin corrosion/irritation | Category 3 | - | Warning | H316: Causes mild skin irritation | P332+P313: If skin irritation occurs: Get medical advice/attention. | Based on the description in the report on rabbit skin irritation tests (RTECS (2006) and IUCLID (2000)): "Mild," "slightly irritating." The substance is thus considered a mild skin irritant. |
3 | Serious eye damage/eye irritation | Category 2B | - | Warning | H320: Causes eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. |
Based on the description in the report on rabbit eye irritation tests (RTECS (2006) and IUCLID (2000)): "Mild," "slightly irritating." The substance is thus considered a mild eye irritant. |
4 | Respiratory sensitization | Category 1 | Danger | H334: May cause allergy or asthma symptoms or breathing difficulties if inhaled |
P304+P341: IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. P342+P311: If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P285: In case of inadequate ventilation wear respiratory protection. P501: Dispose of contents/container to ... |
Based on the description in HSDB (2003) of the human health effects: "The substance induces contact dermatitis and bronchial asthma." | |
4 | Skin sensitization | Category 1 | Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment (see ... on this label). P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
Due to the fact that the substance is classified as a "Skin Sensitizing Substance" by the Japanese Society for Contact Dermatitis. | |
5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Based on the absence of data on in vivo mutagenicity/genotoxicity tests and no positive data on in vitro mutagenicity tests (several indices), described in NTP DB (Access on May 2006), and Report by the Ministry of Health, Labour and Welfare (1997). |
6 | Carcinogenicity | Classification not possible | - | - | - | - | Classification not possible based on expert judgment in the absence of existing classification, though PATTY (4th, 1999) presents toxicity data. |
7 | Reproductive toxicity | Category 2 | Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the evidence of a significant increase in the incidence of exencephalia and malformation of the limbs, tail and eye in the pups observed in teratogenicity studies with Syrian hamsters using intraperitoneal injection, described in PATTY (4th, 1999) (though no data are available regarding parental toxicity). Also based on the evidence of maternal toxicity and teratogenicity observed in rat teratogenicity studies using the oral route of exposure, described in Teratology (1986). | |
8 | Specific target organ toxicity - Single exposure | Category 1 (blood system) | Danger | H370: Causes damage to organs (blood system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment (see ... on this label). P405: Store locked up. P501: Dispose of contents/container to ... |
Based on the human evidence: "p-Aminophenol induces methemoglobinemia" (PATTY (4th, 1999)). | |
9 | Specific target organ toxicity - Repeated exposure | Category 1 (kidney, blood system) | Danger | H372: Cause damage to organs through prolonged or repeated exposure (kidney, blood system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
Based on the human evidence: "p-Aminophenol produces nephrotoxicity; induces methemoglobinemia" (PATTY (4th, 1999)). Also based on the evidence from animal studies including "dark brown urine was observed; urinalysis revealed an increase in epithelial cells; a band of white colored tissue was present at the corticomedullary junction; basophilic renal tubules were found" (Report by the Ministry of Health, Labour and Welfare (1997)), "dose-dependent nephrosis was noted in both sexes at weeks 13 and 27, and in males that had been kept away from the test material at week 7 during the recovery period" (PATTY (4th, 1999)). | |
10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
---|---|---|---|---|---|---|---|
11 | Hazardous to the aquatic environment (Acute) | Category 1 | Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 72 hours ErC50=0.1mg/L of the algae (Selenastrum) (MOE Eco-Toxicity Tests of Chemicals, 1996). | |
11 | Hazardous to the aquatic environment (Long-term) | Category 1 | Warning | H410: Very toxic to aquatic life with long lasting effects |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
Although acute toxicity is Category 1 and bio-accumulation is low (BCF=46(Existing Chemical Safety Inspections Data, )), since there was no rapidly degrading (the decomposition by BOD: 6%(Existing Chemical Safety Inspections Data)), it was classified into Category 1. |
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website (in Japanese Only) |
Model SDS by MHLW |
MHLW Website (in Japanese Only) |