Chemical Name：2-(4-chloro-6-ethylamino-1,3,5-triazin-2-yl)amino-2-methylpropiononitrile
CAS：21725-46-2

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	Based on the rat LD50 (oral route) value of 306mg/kg (Agricultural Chemical Registration Data (1983)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >6,590mg/kg (Agricultural Chemical Registration Data (1983)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >0.809mg/L (4 hours) (Agricultural Chemical Registration Data (1983)).
2	Skin corrosion/irritation	Category 3	-	Warning	H316: Causes mild skin irritation	P332+P313: If skin irritation occurs: Get medical advice/attention.	Based on the description in the report on rabbit skin irritation tests (24 hours, occluded) (PATTY (4th, 1999)): "Mildly irritating."
3	Serious eye damage/eye irritation	Category 2A		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	Based on the description in the report on rabbit eye irritation tests (PATTY (4th, 1999)): "Mild to moderate irritation" and "severe irritation following instillation of 90% formulation, which took about two weeks to resolve." The substance is thus considered a moderate irritant.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Not classified	-	-	-	-	No skin sensitizing potential was found in guinea pig sensitization tests employing the Buehler method (Agricultural Chemical Registration Data (1998)).
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in in vitro assays (reverse mutation tests, chromosome aberration tests and unscheduled DNA synthesis tests) and in vivo assays (mouse chromosome aberration tests, dominant lethal tests and unscheduled DNA synthesis tests) (Agricultural Chemical Registration Data (1983, 1996, 1997)).
6	Carcinogenicity	Not classified	-	-	-	-	There was no treatment-related increase in tumor incidence observed in carcinogenicity studies in rats and mice (Agricultural Chemical Registration Data (1983, 1996)).
7	Reproductive toxicity	Not classified	-	-	-	-	Based on no evidence of adverse effects on reproduction or offspring development observed in rat 3-generation reproduction studies and rat/rabbit teratogenicity studies (Agricultural Chemical Registration Data (1983)).
8	Specific target organ toxicity - Single exposure	Category 3 （Narcotic effects）		Warning	H336: May cause drowsiness or dizziness (narcotic effects)	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "lethargy" (RTECS (2003)).
9	Specific target organ toxicity - Repeated exposure	Category 2 (kidney, heart)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (kidney, heart)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "acute renal failure, acute renal tubular necrosis, and myocardiosis including myocardial infarction" (RTECS (2003)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (kidneys) and Category 2 (heart). Since the referenced study (RTECS (2003)) is assigned a priority rating of 2, these effects are classified into Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from ErC50=20microg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Although acute toxicity is Category 1 and bio-accumulation is low (log Kow=2.22(PHYSPROP Database, 2005)), since there was no rapidly degrading (BIOWIN), it was classified into Category 1.