Chemical Name：2,2-Dichloro-N-[2-hydroxy-1-(hydroxymethyl)-2-(4-nitrophenyl)ethyl]acetamide; Chloramphenicol
CAS：56-75-7

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LD50 (oral route) value of 2,500mg/kg (RTECS (2006)).
1	Acute toxicity （Dermal）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is "solid" according to the GHS definition and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	Insufficient data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 1B		Danger	H340: May cause genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on negative data on multi-generation mutagenicity tests (dominant lethal tests), positive data on germ cell mutagenicity tests in vivo (chromosome aberration tests) and somatic cell mutagenicity tests in vivo (chromosome aberration tests), and the absence of data on germ cell genotoxicity tests in vivo, described in IARC 50 (1990) and IARC 10 (1976).
6	Carcinogenicity	Category 1B		Danger	H350: May cause cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Due to the fact that the substance is classified as Category R by NTP (2005) and Group 2A by IARC (1990).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of pup malformation including hydrocephalus and cleft palate observed in rat teratogenicity studies, described in IARC 10 (1976) (though no data are available regarding parental toxicity).
8	Specific target organ toxicity - Single exposure	Classification not possible	-	-	-	-	No data available
9	Specific target organ toxicity - Repeated exposure	Category 1 (bone marrow, nervous system, digestive system), Category 2 (heart)		Danger Warning	H372: Cause damage to organs through prolonged or repeated exposure (bone marrow, nervous system, digestive system) H373: May cause damage to organs through prolonged or repeated exposure (heart)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the human evidence: "a case report of a 5-yr-old child who developed aplastic anemia and died of acute myeloblastic leukemia 1 year after chloramphenicol was therapeutically administered," "a case of a 63-yr-old man who developed bone marrow suppression 4 months after chloramphenicol was administered at a dose of 12g" (IARC 10 (1976)), "other adverse effects of prolonged administration included skin eruption, gastrointestinal disorder and nervous system damage" (IARC 50 (1990)), "there is symmetrical loss of ganglion cells from retina and atrophy of fibers in optic nerve," "cardiovascular collapse with cardiomyopathic changes and impaired left ventricular function was documented by echocardiography" (HSDB (2005)). Since the priority rating of the referenced study reporting the effects on the heart in humans is 2, these effects are classified into Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available