Chemical Name：N-propyl-N-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide
CAS：67747-09-5

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 5	-	Warning	H303: May be harmful if swallowed	P312: Call a POISON CENTER or doctor/physician if you feel unwell.	Based on the rat LD50 (oral route) value of 2,655mg/kg (Agricultural Chemical Registration Data (1996)).
1	Acute toxicity （Dermal）	Not classified	-	-	-	-	Based on the rat LD50 (dermal route) value of >5,000mg/kg (Agricultural Chemical Registration Data (1996)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Due to the fact that the substance is a solid according to the GHS criteria and inhalation of its gas is not expected.
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	Classification cannot be determined, though the available rat inhalation study reported the LC50 value of >2.16mg/L (4 hours) (Agricultural Chemical Registration Data (1996)).
2	Skin corrosion/irritation	Not classified	-	-	-	-	Based on no evidence of irritation observed in rabbit skin irritation tests (Agricultural Chemical Registration Data (1996)).
3	Serious eye damage/eye irritation	Not classified	-	-	-	-	Based on the evidence of mild irritation occurring immediately after exposure, with effects resolving by 24 hours, observed in rabbit eye irritation tests (Agricultural Chemical Registration Data (1996)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	Insufficient data available
5	Germ cell mutagenicity	Not classified	-	-	-	-	Based on negative data in reverse mutation tests in bacteria, in vitro DNA repair tests, in vitro chromosome aberration tests, gene mutation tests on mouse lymphoma cells, in vitro unscheduled DNA synthesis tests, mouse in vivo micronucleus tests and mouse dominant lethal tests (Agricultural Chemical Registration Data (2003)).
6	Carcinogenicity	Not classified	-	-	-	-	Due to the fact that the substance is classified as Category C by EPA (1997).
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence of "a decreased number of live-born pups with an increase in the stillbirth rate" and "decreased postnatal viability" at doses causing a reduction in parental body weight gain observed in rat 2-generation reproduction studies. Also based on the evidence of "incomplete ossification of the sternum/vertebral arch" and "a decreased number of live fetuses/tendency of increased fetal mortality" at parentally toxic doses observed in rat teratogenicity studies (Agricultural Chemical Registration Data (2003)).
8	Specific target organ toxicity - Single exposure	Category 2 (nervous system, accessory reproductive organs)		Warning	H371: May cause damage to organs (nervous system, accessory reproductive organs)	P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P405: Store locked up. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "central nervous system depressant effects, hunchback position, increased salivation, hypothermia, ataxia, bradypnea, lacrimation, tremors and convulsions" (JMPR (2001)), "effects on the prostate, seminal capsule, Cowper cyst and accessory gland" (RTECS (2006)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (accessory reproductive organs) and Category 2 (nervous system). Since the referenced study for the accessory reproductive organs (RTECS (2006)) is assigned a priority rating of 2, these effects are classified into Category 2.
9	Specific target organ toxicity - Repeated exposure	Category 2 (liver)		Warning	H373: May cause damage to organs through prolonged or repeated exposure (liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Based on the evidence from animal studies including "lipogenesis of perilobular hepatocytes," "periportal vacuolization," and "increased fatty-droplet deposition in hepatocytes" (Agricultural Chemical Registration Data (1996)). These effects were observed at dosing levels within the guidance value ranges for Category 2.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 2	-	-	H401: Toxic to aquatic life	P273: Avoid release to the environment. P501: Dispose of contents/container to ...	It was classified into Category 2 from 72 hours ErC50=1.54mg/L of the algae (Green Algae) (Agricultural Chemical Registration Data, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 2		-	H411: Toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Since acute toxicity was Category 2, there was no rapidly degrading (BIOWIN) and there was bio-accumulation (log Kow=4.1(PHYSPROP Database, 2005)), it was classified into Category 2.