GHS Classification Result

Chemical Name：4,4'-Methylenebis(2-methylcyclohexaneamine)
CAS：6864-37-5

Result：
ID: 559
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Containing no chemical groups with explosive properties
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Classified as "liquid" according to GHS definition
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Classified as "liquid" according to GHS definition
5 Gases under pressure Not applicable - - - - Classified as "liquid" according to GHS definition
6 Flammable liquids Not classified - - - - The flash point is 173degC (c.c.) (IUCLID (2000))
7 Flammable solids Not applicable - - - - Classified as "liquid" according to GHS definition
8 Self-reactive substances and mixtures Not applicable - - - - Containing no chemical groups with explosive or self-reactive properties
9 Pyrophoric liquids Not classified - - - - Not pyrophoric when in contact with air at ordinary temperatures (flash point: 275degC (IUCLID, 2000)).
10 Pyrophoric solids Not applicable - - - - Classified as "liquid" according to GHS definition
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Containing no metals or metalloids (B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At)
13 Oxidizing liquids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine
14 Oxidizing solids Not applicable - - - - Classified as "liquid" according to GHS definition
15 Organic peroxides Not applicable - - - - Organic compounds containing no "-O-O-" structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on the rat LD50 (oral route) value of 550mg/kg (SIDS (2005)).
1 Acute toxicity （Dermal） Classification not possible - - - - Insufficient data available
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Due to the fact that the substance is "liquid" according to the GHS definition and inhalation of its gas is not expected.
1 Acute toxicity （Inhalation: Vapours） Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the rat LC50 value of 0.003ppm (4 hours), calculated from the testing data of rat LC50 (inhalation of vapour) of 0.40mg/L, 0.42mg/L and 0.44mg/L (SIDS (2005)), was lower than 90% of the saturated vapour concentration (80ppm) under a saturated vapour pressure of 0.08kPa (20degC) (SIDS (2005)), the substance was considered as "vapour containing substantially no mist" and was classified based on standard values expressed in ppm.
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the description in the report on rabbit skin irritation tests (SIDS (2005)): "Corrosive." Although classified into Category 1A-1C, the substance should be placed in Category 1A from the viewpoint of safety if further subclassification is needed.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Based on the description in the report on rabbit eye irritation tests (SIDS (2005)): "Corrosive."
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Not classified - - - - Based on the description in the report on a skin painting test and a Maximization test in guinea pigs (SIDS (2005)): "Not sensitizing."
5 Germ cell mutagenicity Classification not possible - - - - Based on the absence of data on in vivo mutagenicity tests and no positive data on in vitro mutagenicity tests (several indices), described in SIDS (2005).
6 Carcinogenicity Classification not possible - - - - No data available
7 Reproductive toxicity Not classified - - - - Histopathological changes, such as seminiferous tubular atrophy, were observed at doses producing general toxicity in repeated dose toxicity studies and teratogenicity studies with rats (SIDS (2005)). However, SIDS attributes these changes to the indirect effects of general toxicity of a severe degree.
8 Specific target organ toxicity - Single exposure Category 2 (nervous system, heart, kidney, respiratory system) Warning H371: May cause damage to organs (nervous system, heart, kidney, respiratory system) P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "sedation, laboured breathing, dyspnea, spasm, arrhythmia, cardiac fibrillation, proteinuria, kidney damage" (BUA 143 (1996)), "corrosive to the respiratory tract; inhalation of aerosols may result in pulmonary edema" (ICSC (J) (2002)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1. However, the referenced studies are assigned a priority rating of 2, the effects are classified into Category 2.
9 Specific target organ toxicity - Repeated exposure Category 1 (kidney), Category 2 (respiratory system, liver, blood system, adrenal gland, heart) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (kidney)
H373: May cause damage to organs through prolonged or repeated exposure (respiratory system, liver, blood system, adrenal gland, heart) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		Based on the evidence from animal studies including "vacuolar degeneration of the nasal mucosa and olfactory epithelium, elevated GOT/GPT, decreased hemoglobin level/mean corpuscular hemoglobin concentration (MCHC), and mild renal tubular nephrosis" (SIDS (2001)), "histological changes in the liver, red blood cell, white blood cell, kidneys, adrenal and heart" (SIDS (2001)). The effects on experimental animals were observed at dosing levels within the guidance value ranges for Category 1 (kidneys) and Category 2 (respiratory organs, liver, blood system, adrenal, heart).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 2 - - H401: Toxic to aquatic life P273: Avoid release to the environment.
P501: Dispose of contents/container to ... 		It was classified into Category 2 from 48 hours EC50=4.6mg/L of the crustacea (Daphnia magna) (MOE eco-toxicity tests of chemicals, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 2 - H411: Toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Although acute toxicity was Category 2 and the bio-accumulation potential was low (BCF=6(Existing Chemical Safety Inspections Data)), since there was no rapidly degrading (the decomposition by BOD: 0%(Existing Chemical Safety Inspections Data)), it was classified into Category 2.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model Label by MHLW

 MHLW Website （in Japanese Only）
Model SDS by MHLW

 MHLW Website （in Japanese Only）

To GHS Information