NITE - Chemical Management Field

GHS Classification Result

Chemical Name：Sodium azide (Na(N3))
CAS：26628-22-8

Result：


ID:	562
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not classified	-	-	-	-	Not classified in UNRTDG Class: 1 and Subsidiary risks Class, though containing azido groups.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	Individual literature citations vary about a flammable. The data with tests defined by the United Nations is not found. It is not classified into the United Nations class 4.1.
8	Self-reactive substances and mixtures	Type G	-	-	-	-	Not classified in UNRTDG Class: 4.1, but Class: 6.1 (though containing azido groups)
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-pyrophoric at a room temperature
11	Self-heating substances and mixtures	Not classified	-	-	-	-	No data available on self-heating
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Hydrogen azide is not generated when it melts in neutral waters.
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Containing no oxygen , chlorine and fluorine.
15	Organic peroxides	Not applicable	-	-	-	-	Inorganic substance
16	Corrosive to metals	Classification not possible	-	-	-	-	Although there is information that it corrodes aluminum strongly, there is no experimental data of the metal corrosion rate. It is not classified into a class 8 according to UNRTDG, either.

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	Category 2 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 45mg/kg; REFERENCE SOURCE: DFGOT vol.20 (2003)
1	Acute toxicity （Dermal）	Category 1		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	Since rabbit percutaneous LD50 value was 20mg/kg (ACGIH (2001)), it was set as Category 1.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	The steam pressure at normal temperature (1 Pa) is less than rat inhalation LC50 (37mg/m3) (RTECS (2004)).
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	It cannot taxonomic according to lack of information. The information on RTECS (2004) is not clear in a chemical exposure forms. (a dust, cracked gas)
2	Skin corrosion/irritation	Category 1C		Danger	H314: Causes severe skin burns and eye damage	P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It judged to be "Category 1C" from corrosivity in animal test result and 4 hour contact (DFGOT vol.20 (2003)).
3	Serious eye damage/eye irritation	Category 1		Danger	H318: Causes serious eye damage	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician.	Since skin corrosivity was Category 1C, the eye was also set to "category 1."
4	Respiratory sensitization	Classification not possible	-	-	-	-	With no sufficient information about causing sensitivity.
4	Skin sensitization	Classification not possible	-	-	-	-	With no sufficient information about causing sensitivity.
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	Although there are positive results from in vitro microbial mutagenicity tests, the in vitro mutagenicity tests in mammalian cells are negative and also there are no data from in vivo tests in mammals. So it was decided that the substance "could not be classified". It is considered that the strong mutagenicity is peculiar to microorganisms and plants. (DFGOT vol.20 (2003)) Category 2, which was based on the in vivo results in muscids, was also suggested in some comments from the experts, but in the end it was concluded that the substance could not be classified.
6	Carcinogenicity	Not classified	-	-	-	-	Since it was judged with A4 by ACGIH, it was set as "Outside of Category."
7	Reproductive toxicity	Classification not possible	-	-	-	-	No data available
8	Specific target organ toxicity - Single exposure	Category 1 (circulatory system)		Danger	H370: Causes damage to organs (circulatory system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since there is a large number of examples about hypotension (be used as therapeutic agents) and suspected the side effects to its respiratory organs, digestive organ, etc. So it was classified into "Category 1."
9	Specific target organ toxicity - Repeated exposure	Category 1 (circulatory system, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (circulatory system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	Since increased sensitivity was seen in some patients when it was used for treatment for high blood pressure for humans over a long-term (ACGIH (2001)) , and the effects on the liver was seen with the given dose below 10mg/kg-day in an animal experiments, it was classified in "Category 1."
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.7mg/L of fishes (Bluegill) (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, not rapidly degrading (direct measurement (HPLC): 1% (existing chemical safety inspections data)), though supposed less bioaccumulative (log Kow<=0.3 (existing chemical safety inspections data).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）