GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Propanenitrile, 2-hydroxy-2-methyl-
CAS：75-86-5
Result：
| ID: | 563 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 6 | Flammable liquids | Category 4 | - | Warning | H227: Combustible liquid |
P370+P378: In case of fire: Use ... for extinction. P403+P235: Store in a well-ventilated place. Keep cool. P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P280: Wear protective gloves/protective clothing/eye protection/face protection. P501: Dispose of contents/container to ... |
Flash point: 74degC, Boiling point: 95degC |
| 7 | Flammable solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not classified | - | - | - | - | Flash point: 685degC and UNRTDG: Class6.1 |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 11 | Self-heating substances and mixtures | Classification not possible | - | - | - | - | Test methods applicable to liquid substances are not available |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At). |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) chemically bonded only to carbon and hydrogen (but not to other elements). |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | No data available on corrosion to metals |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 2 |
|
Danger | H300: Fatal if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
SPECIES: Rat ENDPOINT: LD50 VALUE: 0.017ml/kg (15.8mg/kg) REFERENCE SOURCE: ACGIH (2001) |
| 1 | Acute toxicity （Dermal） | Category 1 |
|
Danger | H310: Fatal in contact with skin |
P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
It was set as Category 1 from rabbit LD50 = 0.017ml/kg (reduced value: 15.8mg/kg) (ACGIH (2001)). |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Liquid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | There is no data for LC50 value, and it cannot be classified. (Since there is a description that with 62.5ppm of inhalation exposure, 2 out of 6 rats died (ACGIH (2001)), it is supposed to be Category 1.) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Category 2 |
|
Warning | H319: Causes serious eye irritation |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. |
Based on data that there was irritation with a rat, it was set as Category 2(CICAD 61 (2004)). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | Although there is a result that the substance does not induce mutagenicity in chromosome aberration or change in rat bone-marrow cells in vivo (CICAD 61(2004)), the test is not for mammals. So it was decided that the substance could not be classified. |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | There is no data against carcinogenic properties and rating administrative information. |
| 7 | Reproductive toxicity | Category 2 |
|
Warning | H361: Suspected of damaging fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there is abnormality in scaffold of child in administration dose causing maternal toxicity to pregnancy hamster (ACGIH (2001)), it is classified into the Category 2. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, circulatory system) |
|
Danger | H370: Causes damage to organs (central nervous system, circulatory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the description that "it caused the headache, paralysis, sense of exhaustion, bilious vomiting, and walk difficulty, and after the symptoms such as cyanosis, coma, and evanescen disturbance of mouth opening, it takes 10 days for recovering with no sequelae" in the example of an accident in human transdermal exposure (ACGIH (2001)), it was classified into Category 1 (central nervous system, circulatory system). The effects of circulatory organ systems, such as tachycardia, respiratory distress, respiratory paralysis are observed also in dermal exposure of guinea pigs at 1.5ml (weight equivalent: 1395mg/kg (it corresponds to the 1000 - 2000mg/kg in guidance value of Category 2 in rat and rabbit.)). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (liver, kidney) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (liver, kidney) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
It was classified in Category 1 by that which has a case of liver and the kidney with the value (5mg/(kg)) of a rat (PATTY (5th, 2001)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available on chemical pneumonia |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 1 |
|
Warning | H400: Very toxic to aquatic life |
P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ... |
It was classified into Category 1 from 48-hour EC50=0.13mg/L of Crustacea (Daphnia magna) (SIDS, 1997). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since rapidly degrading (completely degraded <60 mg/L (SIDS, 1997)), and less bio-accumulative (log Kow=-0.03 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model Label by MHLW |
MHLW Website （in Japanese Only） |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |