GHS Classification Result

Chemical Name：Chlorine
CAS：7782-50-5

Result：
ID: 570
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - Gas (GHS definition)
2 Flammable gases （including chemically unstable gases） Not classified - - - - Non-combustible (ICSC(J), 2000; etc.)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Category 1 Danger H270: May cause or intensify fire; oxidizer P370+P376: In case of fire: Stop leak if safe to do so.
P220: Keep/Store away from clothing/.../combustible materials.
P244: Keep reduction valves free from grease and oil.
P403: Store in a well-ventilated place. 		Categoly 1 and oxidizing gas (ISO 10156-2)
5 Gases under pressure Low pressure liquefied gas Warning H280: Contains gas under pressure; may explode if heated P410+P403: Protect from sunlight. Store in a well-ventilated place. Low pressure liquefied gas because of the critical temp: 143.8 to 144degC.
6 Flammable liquids Not applicable - - - - Gas (GHS definition)
7 Flammable solids Not applicable - - - - Gas (GHS definition)
8 Self-reactive substances and mixtures Not applicable - - - - Gas (GHS definition)
9 Pyrophoric liquids Not applicable - - - - Gas (GHS definition)
10 Pyrophoric solids Not applicable - - - - Gas (GHS definition)
11 Self-heating substances and mixtures Not applicable - - - - Gas (GHS definition)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - Gas (GHS definition)
13 Oxidizing liquids Not applicable - - - - Gas (GHS definition)
14 Oxidizing solids Not applicable - - - - Gas (GHS definition)
15 Organic peroxides Not applicable - - - - Gas (GHS definition)
16 Corrosive to metals Classification not possible - - - - Test methods applicable to gas substances are not available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Classification not possible - - - - No data available
1 Acute toxicity （Dermal） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Gases） Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was considered as Category 2 based on each 4-hour equivalent of two data of a rat being LC50 = 146ppm (EHC 21 (1982), ACGIH (2005)).
1 Acute toxicity （Inhalation: Vapours） Not applicable - - - - Gas (GHS definition)
1 Acute toxicity （Inhalation: Dusts and mists） Not applicable - - - - Gas (GHS definition)
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was classified as Category 1A-1C based on the descriptions that there is a case where it produced slight burn to the human face with exposure to chlorine gas (EHC 21 (1982)) and that corrosivity may be seen on skin (HSDB (2005)). In addition, there are descriptions that "frostbite and corrosivity. Skin burns and pain." as primary disaster/acute manifestation when liquid chlorine touches the skin (ICSC (J), (2000)) and that liquid chlorine causes chilblain and a burn (HSDB (2005)), contacting liquefied chlorine needs special care. This product is classified as Xi; R36/R37/R38 in EU (EU Annex I (2005)).
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician. 		Although mild by level at a There is statement that irritation was acknowledged in the ophthalmic by the monkey (PATTY (5th, 2001)), and that from mild to severe irritation on human depend on concentration, but that all are recovered for a short times (EHC 21 (1982)), and there is a statement that irritation may acknowledge in the ophthalmic of human, and a critical or permanent obstacle may be done (HSDB (2005)). The case of being the highest-risk was taken among these information, and it was set as Category 1. In addition, this product is classified into Xi; R36/R37/R38 by EU.
4 Respiratory sensitization Classification not possible - - - - Since data is insufficient, it cannot be classified.
4 Skin sensitization Classification not possible - - - - No data
5 Germ cell mutagenicity Not classified - - - - There are no data from multi-generation epidemiological and mutagenicity tests in humans, and there is a report of a negative result in an in vivo micronucleus test in mammals (mice). So the substance was regarded as outside the categories.
6 Carcinogenicity Not classified - - - - It was set as the outside of Category based on being classified into the group 3 according to IARC (ACGIH-TLV (2005)), and classified into A4 according to ACGIH (ACGIH (2005)).
7 Reproductive toxicity Not classified - - - - Based on the description of no effect to the reproductive potential of parents and the development and growth of neonatal in the test of rat and mouse (EHC 21 (1982), IRIS (2002), IUCLID (2000)), and no effect to every stage from pregnancy to lactation in chlorine plant employees (EHC 21 (1982)), it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system, nervous system) Danger H370: Causes damage to organs (respiratory system, nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment （see ... on this label）.
P405: Store locked up.
P501: Dispose of contents/container to ... 		In mouse, rabbit, and dog, in the equivalent dose to the amount of exposure of guidance value of Category 1, respiratory disorders, such as pulmonary edema, haemorrhage lung, decrease of lung function, bronchitis, and tract epithelium necrosis, are observed. The similar disorders are observed also in rat with no descritption of dosage (EHC 21 (1982)). Moreover, in mouse, cat, rabbit and guinea pig, there are also the descriptions of the inflammation of respiratory tract membrane, choking, breathing-rate reduction, and upper respiratory tract irritation (EHC 21 (1982), ACGIH (2005), PATTY (5th, 2001)). Also in humans, disorder or irritation to respiratory system, such as pneumonia, pulmonary edema, bronchitis, tracheal ulcer, decrease of lung function, asthma and asthmatic symptoms (RADS), irritation to throat or nose, cough, and breathing difficulties are described (EHC 21 (1982), ACGIH (2005), PATTY (5th, 2001)). It was classified into Category 1 (respiratory systems) based on these information. It was classified into Category 1 (nerve systems) based on the description that it causes vomiting, headache, sense of uneasiness, syncope, fatigue, etc. and also causes photosensitivity enhancement and direct effect to the cerebral cortex in humans (EHC 21 (1982), PATTY (5th, 2001)).
9 Specific target organ toxicity - Repeated exposure Category 1 (respiratory system, kidney, olfactory organ), Category 2 (tooth) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (respiratory system, kidney, olfactory organ)
H373: May cause damage to organs through prolonged or repeated exposure (tooth) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		There are a publication that a disorder is done to lungs with the dosage of guidance value range of the Category 1 in an inhalation experiment of a rat and a mouse, and a publication (EHC 21 (1982), PATTY (5th, 2001), IUCLID (2000)) that the airway epithelium inflammation and histologic changes were seen. A potential of causing a bronchus disease and pulmonary hemorrhage in humans is pointed out (EHC 21 (1982)), and the views on a cough, the pain of a throat, coughing up of blood,chest pains, etc. are indicated (ACGIH (2005)). Moreover, there is also statements that there are fears of lung permanent failure and a chronic bronchitis (HSDFS (1998), SITTIG (4th, 2002)). It was classified in Category 1 (respiratory systems) based on these information. It was classified in Category 1 (kidney) based on the statement (PATTY (5th, 2001)) that biochemical changes which indicates the effects on kidney function was seen with the dosage of guidance value range of Category 1 in the rat inhalation experiments. It was classified in Category 1 (olfactus organ) and Category 2 (tooth), based on descriptions in EHC 21 (1982) and PATTY (5th, 2001) that dysosmia was caused in humans, and descriptions in HSDFS (1998) and SITTIG (4th, 2002) that a disorder is done to a tooth. In addition, although there was a publication (IRIS (2002)) that the dosage of guidance value range of Category 2 indicated 10%-20% of underweight in oral administration to mice and rats as compared with the control, it was considered the secondary effects under influence on a respiratory-organs system or the kidney.
10 Aspiration hazard Not applicable - - - - Gas (GHS definition)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=14microg/L of fishes (Rainbow trout) (IUCLID, 2000).
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, and behavior in water and bioaccumulative potential are unknown.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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