NITE - Chemical Management Field

GHS Classification Result

Chemical Name：chlordane , pur
CAS：57-74-9

Result：


ID:	572
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Classification not possible	-	-	-	-	No data available
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Classification not possible	-	-	-	-	No data available
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	No data available
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Judging from the description that "it does not burn itself due to its noncombustibility" (NAERG (J), (2001)), even if it contacts air at room temperature, it does not ignite spontaneously.
11	Self-heating substances and mixtures	Not classified	-	-	-	-	It is based on the description "it is nonflammable and does not burn itself" (NAERG (J) (2001)).
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing chlorine (but not oxygen and fluorine) and the chlorine is chemically bonded only to carbon (but not to other elements).
15	Organic peroxides	Not applicable	-	-	-	-	Containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available. Melting point: >55degC

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 4		Warning	H302: Harmful if swallowed	P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ...	11 rat LD50 values corresponded (EHC 34 (1984), IARC vol.79 (2001), ACGIH (2001), JMPR 180 (1970)), and it was set as Category 4 based on 314 mg/kg from statistical calculations.
1	Acute toxicity （Dermal）	Category 3		Danger	H311: Toxic in contact with skin	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P280: Wear protective gloves/protective clothing/eye protection/face protection. P312: Call a POISON CENTER or doctor/physician if you feel unwell. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	In the rat and rabbit data, lower rat LD50 value was adopted (EHC 34 (1984)). It was set as Category 3 based on LD50 = 205 mg/kg (the lower one among two LD50).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	Since LC50 value on rodent is unknown, it cannot be classified only based on the data on cats (RTECS (2005)).
1	Acute toxicity （Inhalation: Dusts and mists）	Classification not possible	-	-	-	-	No data available
2	Skin corrosion/irritation	Category 2		Warning	H315: Causes skin irritation	P302+P352: IF ON SKIN: Wash with plenty of soap and water. P332+P313: If skin irritation occurs: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P362: Take off contaminated clothing and wash before reuse.	It is reported that when human skin was irritated by exposed (HSDB (2005), HSFS (2005)), a feeling of warmth, itching, and rash often appear (ATSDR (1994), HSFS (2005)). Animal data which follows standard skin irritation test is not found. But in single or repeated exposure tests, description that "a severe irritation is caused" is seen about skin symptoms (EHC 34 (1984)). Based on what mentioned above, this product is thought to have irritativeness and it was classified as Category 2.
3	Serious eye damage/eye irritation	Category 2A-2B		Warning	H319: Causes serious eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection.	It was set as Category 2A-2B based on the description that stimulates eyes or mucosa according to an accident to humans (HSDB (2005), HSFS (2005)), that atomizing of the mixture which includes this product always starts conjunctivitis (ATSDR (1994)).
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Category 2		Warning	H341: Suspected of causing genetic defects	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Although several dominant lethal tests in mice (in vivo multi-generation mutagenicity tests) were negative (EHC 34(1984), IARC 79(2001)), there are positive results from the in vivo micronucleus test and chromosome aberration test (the in vivo mutagenicity test in somatic cells) (ATSDR (1994), IARC 79(2001)). Some in vivo genotoxicity tests (DNA damage tests, sister chromatid exchange tests) are also positive (IARC 79(2001)). So the substance was classified as Category 2.
6	Carcinogenicity	Category 2		Warning	H351: Suspected of causing cancer	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 based on being classified into 2B by IARC (2001), and into 2B by Japan Society for Occupational Health (2002), and being classified into A3 according to ACGIH (1996), respectively.
7	Reproductive toxicity	Category 2		Warning	H361: Suspected of damaging fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	With exposure in perinatal or lactational periods, the increase of the child mortality rate during lactation period is observed (ATSDR (1994), EHC 34 (1984), IRIS (1997)) ,and neurobehavioral effects are observed in some cases (IARC 79 (2001), ATSDR (1994)). Development of general toxicity of the examination substance is also described at such dose (EHC 34 (1984), IRIS (1997)). Therefore, it was classified into Category 2. In addition, although the increase in mortality rate of child during lactation period is observed, there is also a report that indicates the possibility that it is the influence via lactation (ATSDR (1994), IRIS (1997)).
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system, liver)		Danger	H370: Causes damage to organs (nervous system, liver)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	There are many reports of neurological symptoms, such as spasm, vomiting, ataxia, and distraction after being exposed to humans (IARC 79 (2001), EHC 34 (1984), PIMs (2000)). Moreover, the elevation of liver enzymes is reported (IARC 79 (2001)). On the other hand, it is described that the significant increase in the lipid peroxidation of the liver was observed in the rat (IARC 79 (2001)). Based on these findings in human and animal it was classified into Category 1 (nervous systems, liver).
9	Specific target organ toxicity - Repeated exposure	Category 1 (liver, nervous system, brainblood vessels, blood)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (liver, nervous system, brainblood vessels, blood)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	In two or more examinations using a rat, a mouse, and a dog, a rise of liver enzymes, an increase in liver weight, and the hepatocytes enlargement accompanied by histologic changes, such as uniformity, margination of cytoplasm, and a necrosis, are seen with a low doses (IARC 79 (2001), EHC 34 (1984), JMPR 080 (1967), and IRIS (1997)), moreover, a spasm, a trembling, the influence on autonomic nerves and a sense organ, etc. are seen (IARC 79 (2001), EHC 34 (1984)). Moreover, in investigation of the humans who received prolonged exposure by aerosols, neurophysiological effect is ascertained (IRIS (1997), JMPR 080 (1967)), and there is also a report (IRIS (1997)) of a cerebrovascular disease, anemia and a decrease of platelets by occupational exposure or epidemiological study. It was classified in Category 1(liver,nervous systems, cerebrovascular, blood) based on the above result.
10	Aspiration hazard	Classification not possible	-	-	-	-	Insufficient data available.

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.4microg/L of Crustacea (Pink shrimp), and others (EHC34, 1984).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=27900 (existing chemical substances safety inspections data)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）