GHS Classification Result

Chemical Name:Ethyl acetate
CAS:141-78-6

Result:
ID: 579
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Category 2 Danger H225: Highly flammable liquid and vapour P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P370+P378: In case of fire: Use ... for extinction.
P403+P235: Store in a well-ventilated place. Keep cool.
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P233: Keep container tightly closed.
P240: Ground/bond container and receiving equipment.
P241: Use explosion-proof electrical/ventilating/lighting/.../equipment.
P242: Use only non-sparking tools.
P243: Take precautionary measures against static discharge.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P501: Dispose of contents/container to ...
Flash point: <23degC, Initial Boiling point: >35degC
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Not classified - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not classified - - - - It is accepted that, even if it contacts air in room temperatures, it does not igniting spontaneously from the experience in manufacture and treatment.
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Organic compounds containing oxygen chemically bonded only to carbon (but not to other elements).
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - There is no data. Acetate which is one of the hydrolysis products corrodes aluminum.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Not classified - - - - Based on that all of oral rat LD50 values are more than 5000 mg/kg (ACGIH (2001), DFGOT (vol.12 1991), and Patty (5th. (2001)), it was set as the outside of Category.
1 Acute toxicity (Dermal) Not classified - - - - It was set as outside of Category based on the rabbit was not died at 18000mg/kg (DFGOT (vol.12.1991)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Not classified - - - - Maximum vapor concentration is 350g/m3 (20degC). (GESTIS(2005)) As the highest result, LC50: 57.6g/m3 (ACGIH (1991)) is below saturated concentration, it is interpreted as not being mist. Since even the lowest LC50 value: 14620ppm (DFGOT (vol.12.1999)) is 2.5 times more than the limit of Category 4: 2000ppm, it was classified as out of Category.
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Not classified - - - - As it caused "no irritation" in tests on humans (DFGOT (vol.12, 1999)) and rabbits (IUCLID (2000)), it was classified as "out of Category". Observed effect was "defatting" with long-term repeated skin exposure only.
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
The irritation was seen in the eye of the rabbit. But it recovered within seven days (ECETOC (TR48 (2), 1998)). So it was set as "Category 2B".
4 Respiratory sensitization Classification not possible - - - - Literature was not able to be obtained about respiratory sensitization.
4 Skin sensitization Not classified - - - - It was put "outside of the Category" based on the skin sensitization test results of the humans and rabbits. (IUCLID (2000), DFGOT (vol.12, 1991))
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as "outside the categories" based on negative results from in vivo micronucleus tests. (DFGOT (vol.12, 1991), IUCLID (2000))
6 Carcinogenicity Classification not possible - - - - Classification not possible due to lack of data
7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data
8 Specific target organ toxicity - Single exposure Category 1 (respiratory system), Category 3 (narcotic effects) Danger
Warning
H370: Causes damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects)
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
The upper respiratory tract irritation in human at 400ppm exposure is reported (ACGIH (2001), DFGOT (vol.12, 1999)). Anesthesia and lung injury are reported by explosion of near lethal level (DFGOT (vol.12, 1999)). "A respiratory-organs system : Category 1", and "Anesthesia : Category 3" were applied.
9 Specific target organ toxicity - Repeated exposure Classification not possible - - - - The case in human work exposure is combined exposure, and cannot be judged only now. Animal experiments inhalation exposure concentrations exceeds the guidance value maximum (250 ppm or 1 mg/L) of Category 2.
10 Aspiration hazard Classification not possible - - - - No data available on chemical pneumonia, though it could be classified based on the criteria 2b with the dynamic viscosity at 25degC and 40degC.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour EC50=164mg/L of Crustacea (Water flea) (IUCLID, 2000).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility =80000 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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