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GHS Classification Result

Chemical Name：dioxathion
CAS：78-34-2

Result：


ID:	585
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Liquid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Liquid (GHS definition)
6	Flammable liquids	Not classified	-	-	-	-	Non-combustible (ICSC, 1998; Sax, 11th, 2004; HSDB, 2005).
7	Flammable solids	Not applicable	-	-	-	-	Liquid (GHS definition)
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.
9	Pyrophoric liquids	Not classified	-	-	-	-	Non-combustible (ICSC, 1998; Sax (11th, 2004); HSDB , 2005)
10	Pyrophoric solids	Not applicable	-	-	-	-	Liquid (GHS definition)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Non-combustible (ICSC (1998), Sax (11th, 2004), HSDB (2005))
12	Substances and mixtures which, in contact with water, emit flammable gases	Not classified	-	-	-	-	Since measurement of water solubility, a water-octanol distribution coefficient, etc. is performed (ICSC (1998) etc.), it is judged that it is stable in the water.
13	Oxidizing liquids	Classification not possible	-	-	-	-	Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to phosphorus.
14	Oxidizing solids	Not applicable	-	-	-	-	Liquid (GHS definition)
15	Organic peroxides	Not applicable	-	-	-	-	Organic compounds containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	No data available

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 2		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 2 based on LD50= 29mg/kg obtained from the calculation using six data of rat LD50 values (ACGIH (2002), JMPR 125 (1968)).
1	Acute toxicity （Dermal）	Category 2		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	LD50= 67.6mg/kg calculated from four data (ACGIH (2002), PATTY (5th, 2001)) of rat LD50 value. And LD50= 85mg/kg of two data (equivalence) of rabbit LD50 value. It was set as Category 2 based on LD50= 67.6mg/kg of the lower value.
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Liquid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 2		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Since the saturated vapor pressures concentrations pressure of this product is 0.000115mg/L (6*10^(-7)ppm), it is thought that the inhalation study was done in mist. It was set as category 2 based on rat LC50 = 0.3495mg/L (ACGIH (2002)).
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	No data available
3	Serious eye damage/eye irritation	Category 2B	-	Warning	H320: Causes eye irritation	P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P337+P313: If eye irritation persists: Get medical advice/attention. P264: Wash ... thoroughly after handling.	Mild and transient conjunctivitis is produced in a rabbit. But there was no effect in a corneal (ACGIH (2002), PATTY (5th, 2001), HSDB (2005)). And that there were the haze eye and stimulativeness in humans (ICSC (J) (1998), HSFS (1998)). So it was set as Category 2B.
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Classification not possible	-	-	-	-	It was decided that the substance could not be classified by the technical guidelines. Because there are no results from in vivo tests and there are no records of strong positive results in vitro tests in several parameters.
6	Carcinogenicity	Not classified	-	-	-	-	Not classified because of
7	Reproductive toxicity	Not classified	-	-	-	-	Since there is the description that there is no malformation in the parent animals, next generation and the third generation in the rat three generation test (ACGIH (2002), PATTY (5th, 2001)), and there is the description that there is no abnormal findings of parent animals of rat, and no bad effect to the reproductive behavior fertility and to the number of a lactating- litter neonatal, and the size and the anatomic structure of neonatal is normal (JMPR 125 (1968)), it was considered as on the outside of Categry.
8	Specific target organ toxicity - Single exposure	Category 1 (nervous system)		Danger	H370: Causes damage to organs (nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Due to the description that miosis, muscle spasticity, salivation, sweating, nausea, dizziness, closeness, convulsion, incoordination, loss of consciousness, etc. were observed in human (ACGIH (2002), PATTY (5th, 2001), ICSC (J) (1998), HSFS (1998)), it was classified into Category 1 (nerve system).
9	Specific target organ toxicity - Repeated exposure	Category 1 (nervous system)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (nervous system)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified in Category 1 (nervous systems) based on the statements that inhibition of cholinesterasethe in plasma and a red corpuscle,hyperexcitability, tremor in rats and dogs with the dosage of guidance value range of Category 1 (ACGIH (2002), PATTY (5th, 2001)), and the statements of the cholinesterase inhibition in plasma by repeated exposure also in humans (ACGIH (2002), PATTY (5th, 2001), JMPR 125 (1968), HSDB (2005)).
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 48-hour EC50=0.35microg/L of Crustacea (Daphnia magna) (HSDB, 2004).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.45(PHYSPROP Database, 2005)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model Label by MHLW	MHLW Website （in Japanese Only）
Model SDS by MHLW	MHLW Website （in Japanese Only）