GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Dimethylamine
CAS：124-40-3
Result：
| ID: | 589 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Flammable gases （including chemically unstable gases） | Category 1 |
|
Danger | H220: Extremely flammable gas |
P210: Keep away from heat/sparks/open flames/hot surfaces. - No smoking. P377: Leaking gas fire: Do not extinguish, unless leak can be stopped safely. P381: Eliminate all ignition sources if safe to do so. P403: Store in a well-ventilated place. |
Ignitable when in a mixture of 13% or less by volume in air. UNRTDG Class: 2.1 |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not classified | - | - | - | - | Not classified in UNRTDG Subsidiary risks Class: 5.1 |
| 5 | Gases under pressure | Liquefied gas |
|
Warning | H280: Contains gas under pressure; may explode if heated | P410+P403: Protect from sunlight. Store in a well-ventilated place. | Critical temp: >-50degC (Partially liquid at temperatures above -50degC) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 7 | Flammable solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 10 | Pyrophoric solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 11 | Self-heating substances and mixtures | Not applicable | - | - | - | - | Gas (GHS definition) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not applicable | - | - | - | - | Gas (GHS definition) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Gas (GHS definition) |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Gas (GHS definition) |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Liquid at a test temperature, 55degC. Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 4 (Aqueous solution) |
|
Warning | H302: Harmful if swallowed (Aqueous solution) |
P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P330: Rinse mouth. P501: Dispose of contents/container to ... |
As a result of the examination using water solutions, based on rat LD50 value: 698mg/kg (ACGIH (7th, 2001), DFGOT vol.7 (1996)), it was set as Category 4. (water solutions) |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Category 4 |
|
Warning | H332: Harmful if inhaled |
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P312: Call a POISON CENTER or doctor/physician if you feel unwell. |
It was considered as Category 4 based on rat LC50 (4 hours) value: 4700 ml/m3 (DFGOT vol.7 (1996)). |
| 1 | Acute toxicity （Inhalation: Vapours） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Not applicable | - | - | - | - | Gas (GHS definition) |
| 2 | Skin corrosion/irritation | Category 1A-1C (3-6% solution) |
|
Danger | H314: Causes severe skin burns and eye damage (3-6% solution) |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
There are descriptions that in 3 or 6% aqueous solutions skin application test on rabbits, erythema and edema, and following ulcer was observed of the skin (DFGOT vol.7, 1996, ACGIH, 7th, 2001) and that the test inwhich the tip of mice tail was dipped in 6% aqueous solutions for 2 hours, congestion with a clear boundary and following tissue necrosis was observed (DFGOT vol.7, 1996, ACGIH, 7th, 2001). It was judged to have corrosivity and was classified as Category 1A-1C (3-6% aqueous solutions). Since the details of development and course of the corrosive reaction were unknown, it was not subcategorized. |
| 3 | Serious eye damage/eye irritation | Category 1 (1-5% solution) |
|
Danger | H318: Causes serious eye damage (1-5% solution) |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
To eye of rabbit, conjunctivitis, conjunctival edemas, keratitis and corneal opacity are caused 1% aqueous solution, and conjunctival hemorrhage, corneal edemas, turbidity and neovascularization are caused 5% aqueous solution, and it will continue 28 days. Furthermore, in higher concentrations, skin corrosiveness that a corneal becomes the translucent of blue and white in several seconds (DFGOTvol.7 (1996), ACGIH 7th, (2001)). So it was set as Category 1 (1-5% water). |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data |
| 4 | Skin sensitization | Category 1 |
|
Warning | H317: May cause an allergic skin reaction |
P302+P352: IF ON SKIN: Wash with plenty of soap and water. P333+P313: If skin irritation or rash occurs: Get medical advice/attention. P261: Avoid breathing dust/fume/gas/mist/vapours/spray. P272: Contaminated work clothing should not be allowed out of the workplace. P280: Wear protective gloves/protective clothing/eye protection/face protection. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P501: Dispose of contents/container to ... |
In Maximization test (closed epicutaneous test) using a guinea pigs, it is positive (the rate of positivity: 100%) (DFGOTvol.7 (1996)) and, as a description states that this substance has skin sensitization (ACGIH 7th, 2001), it was referred to as Category 1. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | Although there are no data from the tests in germ cells, the report of the negative result of the in vivo chromosome aberration test using bone-marrow cells taken from rats that have been subjected to exposure to this substance for 3 months through inhalation (DFGOTvol.7 (1996)). So the substance was regarded as outside the categories. |
| 6 | Carcinogenicity | Not classified | - | - | - | - | Since it was classified into A4 according to ACGIH (7th, 2001), it carried out the outside of Category. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (central nervous system, respiratory system) |
|
Danger | H370: Causes damage to organs (central nervous system, respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
Due to the descriptions that the tissue injury is observed in respiratory mucosa by the exposure concentrations at 600ppm or more by single inhalation exposure test in rats (PATTY (5th, 2001)), that the RD50 value in short time inhalation exposure in rat and mouse (50% breathing rates inhibitory concentration) is calculated (DFGOTvol.7 (1996)), that it has respiratory irritantation, and that the central nervous system effects (incoordination and depressomotor) were observed in the dosage of the guidance value of Category 1in the oral administration examination in rat, mouse, rabbit, and guinea pig (ACGIH (7th, 2001)). So it was classified into Category 1(central nervous system, respiratory system). |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (respiratory system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (respiratory system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
In the inhalation exposure test in rats and mice for two years, it was classified to as Category 1 (respiratory systems) from the description that inflammation, denaturation, and hyperplastic injury at the rhinal mucosas were acknowledged in the exposure group of 50 ppm or more of the guidance value range maximum of Category 1(ACGIH (7th, 2001), DFGOT vol.7 (1996), PATTY (5th, 2001)). |
| 10 | Aspiration hazard | Not applicable | - | - | - | - | Gas (GHS definition) |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Category 2 | - | - | H401: Toxic to aquatic life |
P273: Avoid release to the environment. P501: Dispose of contents/container to ... |
It was classified into Category 2 from 96-hour EC50=6200microg/L of algae (Selenastrum) (AQUIRE, 2003). |
| 11 | Hazardous to the aquatic environment （Long-term） | Not classified | - | - | - | - | Since rapidly degrading (BOD: 88% (existing chemical safety inspections data)), and less bio-accumulative (log Kow=-0.38 (PHYSPROP Database, 2005)). |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |