GHS Classification Result

Chemical Name:Demeton-methyl
CAS:8022-00-2

Result:
ID: 590
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - Classification not possible due to lack of data, though it is flammable (ICSC, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Classification not possible due to lack of data, though the substance contains P-O bonds as chemical groups with self-reactive properties present.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - Since aqueous solubility measurements is performed, it judges to be stable in the water (ICSC (2001) etc.).
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data, though organic compounds containing oxygen chemically bonded to phosphorus.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) O-: Category 2, S-: Category 2 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
O-object: It was set as Category 2 based on rat LD50= 30mg/kg obtained from the calculation using eight data (ACGIH (2001), JMPR 264 (1973), JMPR 790 (1989)). S-object: It was set as Category 2 based on rat LD50= 47g/kg obtained from the calculation using six data (ACGIH (2001), PATTY (5th, 2001), JMPR 264 (1973)).
1 Acute toxicity (Dermal) O-: Category 2, S-: Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
O-object: It was set as Category 2 based on LD50 = 100mg/kg calculated from four data (JMPR 264 (1973), JMPR 790 (1989)) of rat LD50 value. S-object: It was set as Category 1 based on LD50 = 45g/kg calculated from four data (PATTY (5th, 2001), JMPR 264 (1973)) of rat LD50 value.
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) O-: Category 2, S-: Category 2 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The saturated vapor pressures concentrations pressure of this product is 0.396ppm (0.00373mg/L), and it is thought that the inhalation study was done in mist. It was set as Category 2 based on LC50 = 0.427mg/L calculated from three data (JMPR 790 (1989)) of O-body: rat LC50 value. It was set as Category 2 based on LC50=0.21mg/L calculated from four data (PATTY (5th, 2001)) of S-body: rat LC50 value.
2 Skin corrosion/irritation O-: Category 3, S-: Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. O-body: Based on the description that although erythema was seen on rabbits, it recovered 72 hours afterward to indicate mild skin irritation (JMPR 790 (1989)), it was classified as Category 3. S-body: Based on descriptions that although slight erythema and edema were observed on rabbits, it disappeared three days afterward (PATTY (5th, 2001) vol.7) and that it has mild irritation on humans (HSDB (2005)), it was classified as Category 3.
3 Serious eye damage/eye irritation O-: Category 2A-2B, S-: Category 2B Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
O-body: In the rabbit, although corneal cloudings, conjunctival redness, and gum of eyelid were seen, it recovered 21 days afterward altogether, and it is thought that it is a stimulant of primaries to eye (JMPR 790 (1989)). Based on above statement it was set as Category 2A-2B. S-body : although tearing and miosis were seen with the rabbit and the slight corneal cloudings, discontinuous redness, and a conjunctiva dropsy were seen, and it disappeared seven days afterward (PATTY(5th, 2001) vol.7, JMPR 264 (1973)), and it had mild irritation in humans (HSDB (2005)). So it was set as Category 2B.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Category 1 (o-form, S-form) Warning H317: May cause an allergic skin reaction (o-form, S-form) P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P333+P313: If skin irritation or rash occurs: Get medical advice/attention.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P272: Contaminated work clothing should not be allowed out of the workplace.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ...
O-object: Based on the statement (JMPR 790 (1989)) that it showed skin sensitivity by the maximization test, the Klecak test, and the patch test with guinea pigs,.it was referred to as Category 1. S-object : Baded on the statement (PATTY(5th, 2001) vol.7, JMPR 790 (1989)) that although the maximization test indicated skin sensitization in guinea pigs, the skin patch tests did not show the sensitization, it was referred to as Category 1.
5 Germ cell mutagenicity O-: Not classified, S-: Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
O-body : The substance was regarded as outside the categories. Because there are no positive results in human multi-generation epidemiological tests, multi-generation mutagenicity tests and in vivo mutagenicity tests using germ cells and somatic cells, and there are records of negative results from the in vivo dominant lethal tests in mice (PATTY (5th, 2001) vol. 7, JMPR 697 (1984)). S-body: The substance was classified as Category 2. Because there are no positive test results from human multi-generation epidemiological tests, multi-generation mutagenicity tests and in vivo mutagenicity tests in germ cells, and there is a record of a negative test result from the in vivo chromosome aberration test using Syrian hamster bone-marrow cells (PATTY (5th, 2001) vol. 7).
6 Carcinogenicity O-: Classification not possible, S-: Classification not possible - - - - O-: Classification not possible due to lack of data S-: Classification not possible due to lack of data
7 Reproductive toxicity O-: Category 2, S-: Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
O-object : since there is the description that there were the significant reduction of the gravidity and of the litter count in rat, the reduction of oogenesis in third generation of 3/10 female, and there is the vacuolating of the epididymis epithelium of parent occurs in dose dependence at the dose no descriptioin about general toxicity to parent (JMPR 790(1988)), and there is the description that there is the reduction of conception rate and survival rate of neonatal in the dose causing reduced weight gain in parent (JMPR 264 (1973)), it is classified into the Category 2. S-object : since there is the description that there is suppress of survival rate, nursing rate, weight gaining in rat, and there is the reduction of the average of weight of embryo in rabbit, with the dose no description about general toxicity to parent (PATTY(5th, 2001) vol.7, JMPR 697 (1984)), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Mixture: Category 1(nervous system), O-: Category 1(nervous system), S-: Category 1(nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
Mixture : In humans, spasm, giddiness, stuffiness, nausea, constricted pupil, muscular spasticity, salivation, sweating, loss of consciousness, stomach cramps, diarrhea, vomiting etc. are observed, and the serum cholinesterase activity is decreased (ACGIH (2001), PATTY(5th, 2001) vol.7, ICSC (J) (2001), HSDB (2005)). So it was classified into Category 1(nerve systems). O-Body : In humans, miosis, muscle spasticity, salivation, sweating, nausea, dizziness, closeness, feeling of weariness, stomach cramp, vomiting, diarrhea, cramp, loss of consciousness, dysphoria, cough, and muscle fasciculation etc., are observed, and the serum cholinesterase activity is decreased (ACGIH (2001), PATTY (5th, 2001) vol. 7, ICSC (J) (2001), HSDB (2005)). So it was classified into Category 1. S-Body : In humans, based on the description that miosis, muscle spasticity, salivation, sweating, nausea, vomited, stomach cramps, diarrhea, dizziness, closeness, feeling of weariness, loss of consciousness, gastrointestinal disorder, fatigue, headach, sweating, lacrimation, tremor, ataxia, hiccup, muscular fasciculation, etc. are observed, and the serum cholinesterase activity is decreased (PATTY (5th, 2001) vol. 7, ICSC (J) (2001)). So it was classified into Category 1 (nerve systems).
9 Specific target organ toxicity - Repeated exposure O-: Category 1(nervous system), S-: Category 1(nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
O-object : It was classified to as Category 1 (nervous systems) since the toxic symptoms of cholinergics are looked, and inhibition of cholinesterase activity in brains, plasma and serum are indicated by the dosage of guidance value within the limits of Category 1in rats (JMPR 264 (1973), JMPR 790 (1989)), and cholinesterase inhibition is indicated in humans (JMPR 264 (1973)). S-object : It was referred to as Category 1 (nervous systems) since the toxic symptoms of the cholinergics (mild tremor and bundle twich) are seen, and inhibition of cholinesterase activity in brains, plasma and serum is indicated in rats and dogs, by the dosage of guidance value within the limits of Category 1(PATTY(5th, 2001) vol.7, JMPR 264 (1973), JMPR 790 (1989)).
10 Aspiration hazard O-: Classification not possible, S-: Classification not possible - - - - No data available (o-, S-)

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour LC50=190microg/L of Crustacea (Amphipod) (AQUIRE, 2003).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=1.11(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

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