GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Potassium hydroxide
CAS：1310-58-3
Result：
| ID: | 598 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible substance (Hommel, 1991) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (Hommel (1997) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible (Hommel, 1991) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Although generation of heat will be carried out if it dissolves in water, combustible gases does not occur. |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Classification not possible | - | - | - | - | Classification not possible, though containing oxygen (but not halogen). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Inorganic compound |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Category 3 |
|
Danger | H301: Toxic if swallowed |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ... |
Category 3 based on SPECIES: Rat; ENDPOINT: LD50; VALUE: 284mg/kg; REFERENCE SOURCE: Priority 1 |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Category 1B |
|
Danger | H314: Causes severe skin burns and eye damage |
P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting. P303+P361+P353: IF ON SKIN （or hair）: Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower. P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P321: Specific treatment （see ... on this label）. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ... |
Since there are descriptions that it was corrosive in rabbit test (SIDS (2001)) and that it has corrosivity on humans (SIDS (2001)), and its UN classification is class 8II. Therefore it was classified as Category 1B. |
| 3 | Serious eye damage/eye irritation | Category 1 |
|
Danger | H318: Causes serious eye damage |
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. |
Since there are statements of irreversible damage with humans (SIDS (2001)), and of corrosive in rabbit test (SIDS (2001)), and since skin caustic / stimulative GHS classifications are in Category 1B, it was categoried into Category 1. |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | It cannot be classified. |
| 4 | Skin sensitization | Not classified | - | - | - | - | There is a negative statement (SIDS (2001)) by guinea pigs test and, since the intravital existence of both potassium ions and hydroxide ion deny the cause of skin sensitization(SIDS(2001))., it was put outside of the division, although there is no report on humans. |
| 5 | Germ cell mutagenicity | Not classified | - | - | - | - | With regard to in vitro tests of potassium hydroxide, there are negative data from the Ames test (SIDS (2001)), but there are no in vivo test data. But sodium hydroxide is negative in in vivo mutagenicity tests in somatic cells (micronucleus tests) and it is also negative in in vivo mutagenicity tests in germ cells (detection of aneuploidy in oocytes), though under restricted conditions (SIDS (2001)). So by analogy we presumed that data from potassium hydroxide could be the same and we judge that it will be appropriate to regard potassium hydroxide as outside the categories |
| 6 | Carcinogenicity | Classification not possible | - | - | - | - | There is no reliable data and there is also no report of evaluation organizations, such as International Agency for Res. on Cancer. So it cannot classify. |
| 7 | Reproductive toxicity | Classification not possible | - | - | - | - | Classification not possible due to lack of data on potassium hydroxide. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (respiratory system) |
|
Danger | H370: Causes damage to organs (respiratory system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into Category 1(respiratory systems) according to the statement that inhalation exposure to the particles or the mist will cause such damages as burns to the nose and bronchial tube and result even in lung edemas (SIDS (2001), ACGIH (2001) and PATTY (5th, 2001)). |
| 9 | Specific target organ toxicity - Repeated exposure | Classification not possible | - | - | - | - | The example for repeated dose in toxicity research of potassium hydroxide is not found. It cannot be classified without a report on humans. |
| 10 | Aspiration hazard | Category 1 |
|
Danger | H304: May be fatal if swallowed and enters airways |
P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P331: Do NOT induce vomiting. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into Category 1 based on the statement of die of pneumonia by aspiration (ACGIH (2001)). |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | Insufficient data available. |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | Classification not possible due to lack of data |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |