GHS Classification Result
PHYSICAL HAZARDS
HEALTH HAZARDS
ENVIRONMENTAL HAZARDS
NOTE:
Reference：
Chemical Name：Lead distearate
CAS：1072-35-1
Result：
| ID: | 600 |
| Classifier: | Inter-ministerial Committee on GHS |
| Year Classified: | FY2006 |
| Reference Manual: | GHS Classification Manual （10 Feb, 2006） |
PHYSICAL HAZARDS
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Explosives | Not applicable | - | - | - | - | There are no chemical groups associated with explosive properties present in the molecules. |
| 2 | Flammable gases （including chemically unstable gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 3 | Aerosols | Not applicable | - | - | - | - | Not aerosol products |
| 4 | Oxidizing gases | Not applicable | - | - | - | - | Solid (GHS definition) |
| 5 | Gases under pressure | Not applicable | - | - | - | - | Solid (GHS definition) |
| 6 | Flammable liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 7 | Flammable solids | Not classified | - | - | - | - | Non-combustible (Weiss (2nd, 1985)) |
| 8 | Self-reactive substances and mixtures | Not applicable | - | - | - | - | There are no chemical groups associated with explosive or self-reactive properties present in the molecule. |
| 9 | Pyrophoric liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 10 | Pyrophoric solids | Not classified | - | - | - | - | Non-combustible (Weiss, 2nd, 1985) |
| 11 | Self-heating substances and mixtures | Not classified | - | - | - | - | Non-combustible (Weiss, 2nd, 1985) |
| 12 | Substances and mixtures which, in contact with water, emit flammable gases | Not classified | - | - | - | - | Since aqueous solubility is measured, it is stable in the water. (Merck (13th, 2001), SRC (2006)) |
| 13 | Oxidizing liquids | Not applicable | - | - | - | - | Solid (GHS definition) |
| 14 | Oxidizing solids | Not applicable | - | - | - | - | Organic compounds containing oxygen (but not chlorine and fluorine) and the oxygen is chemically bonded only to carbon (but not to other elements). |
| 15 | Organic peroxides | Not applicable | - | - | - | - | Organic compounds containing no -0-0- structure |
| 16 | Corrosive to metals | Classification not possible | - | - | - | - | Test methods applicable to solid substances are not available. |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 1 | Acute toxicity （Oral） | Classification not possible | - | - | - | - | Although there are two data (IUCLID (2000)) of rat LD50> 15000mg/kg and LD50> 2000mg/kg, it cannot classify with only these data. |
| 1 | Acute toxicity （Dermal） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Gases） | Not applicable | - | - | - | - | Solid (GHS definition) |
| 1 | Acute toxicity （Inhalation: Vapours） | Classification not possible | - | - | - | - | No data available |
| 1 | Acute toxicity （Inhalation: Dusts and mists） | Classification not possible | - | - | - | - | No data available |
| 2 | Skin corrosion/irritation | Classification not possible | - | - | - | - | No data available |
| 3 | Serious eye damage/eye irritation | Classification not possible | - | - | - | - | No data available |
| 4 | Respiratory sensitization | Classification not possible | - | - | - | - | No data available |
| 4 | Skin sensitization | Classification not possible | - | - | - | - | No data available |
| 5 | Germ cell mutagenicity | Classification not possible | - | - | - | - | No data available |
| 6 | Carcinogenicity | Category 1B |
|
Danger | H350: May cause cancer |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
It was classified into R by NTP(NTP (2005)), into Group 2A by IARC (IARC 87 (2004)), into A3 by ACGIH(ACGIH-TLV (2004)), and into 2B by Japan Society for Occupational Health(JETOC specially data No.190 (2004)). So it was set as Category 1B. |
| 7 | Reproductive toxicity | Category 1A |
|
Danger | H360: May damage fertility or the unborn child |
P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no reproductive toxicity data as lead stearates. However, since lead is known as the development neural toxicity material and reproductive toxicity in human (ACGIH-TLV (2004), ATSDR (draft 2005)), it is classified into the Category 1A. Refer to [ID 168, a lead, CAS NO:439-92-1], [ID 48, oxidization lead (II), CAS NO:1317-36-8], and [lead acetates (II), CAS NO:301-04-2] about health toxicity. |
| 8 | Specific target organ toxicity - Single exposure | Category 1 (blood system, kidney, nervous system) |
|
Danger | H370: Causes damage to organs (blood system, kidney, nervous system) |
P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ... |
There is no information about a single exposure to lead stearate. However, as toxicity of the inorganic lead compounds, besides the inhibition of hemoglobin synthesis induced to humans by delta-aminolevulinic acid and heme synthase inhibition, anemia caused by the shortening of red cell life span, interstitial disorders, the reduction of urinary output, the proximal tubule damages which cause the Fanconi syndromes represented by alubuminuria, bloody urine, urine pillars, glucosuria and amino acid urine, etc. are observed. As they act on the peripheral nerves, especially weakness of the line of the limbs, pain, and convulsion are identified, and as their influences on the central nerve systems such as ataxie, headach, abnormal sebsation, depression, and coma are identified with high concentration exposures. These influences are acute ones |
| 9 | Specific target organ toxicity - Repeated exposure | Category 1 (blood system, kidney, nervous system) |
|
Danger | H372: Cause damage to organs through prolonged or repeated exposure (blood system, kidney, nervous system) |
P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ... |
There is no repetitive exposure information about lead stearate. However, the hemoglobin composition prevention which originated in delta-aminolevulinic acid and heme synthetases inhibition, the anemia by shortening of red cell life span, an interstitial disorders, oliguria, and the proximal tubule damages which assumes the Fanconi syndromes represented by albuminuria, bloody urine, a urinary cast, diabetes, amino acid urine to human as toxicity of the inorganic lead compounds are seen. It acts on the peripheral nerves, especially the weakness, pain, and convulsion of the muscles of extremities are acknowledged, and in high concentration exposures the effects on the central nervous systems such as ataxie, headache, dysesthesia, depression, and a coma, etc. are acknowledged. It was classified to as Category 1 (blood systems, kidney, nervous system), based on these effects which are seen equally in acute effect or chronic effect (ACGIH-TLV (2004)). |
| 10 | Aspiration hazard | Classification not possible | - | - | - | - | No data available |
| Hazard class | Classification | Symbol | Signal word | Hazard statement | Precautionary statement | Rationale for the classification | |
|---|---|---|---|---|---|---|---|
| 11 | Hazardous to the aquatic environment （Acute） | Classification not possible | - | - | - | - | No data available |
| 11 | Hazardous to the aquatic environment （Long-term） | Classification not possible | - | - | - | - | No data available. |
NOTE:
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* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users. * This is a provisional English translation of classification results and is subject to revision without notice. * The responsibility for any resulting GHS labelling and SDS referenced from this site is with users. |
Reference：
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Reference Manual |
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Definitions / Abbreviations |
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Model SDS by MHLW |
MHLW Website （in Japanese Only） |