GHS Classification Result

Chemical Name:fensulfothion
CAS:115-90-2

Result:
ID: 602
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Liquid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Liquid (GHS definition)
5 Gases under pressure Not applicable - - - - Liquid (GHS definition)
6 Flammable liquids Classification not possible - - - - Classification not possible due to lack of data, though it is flammable (ICSC, 2001)
7 Flammable solids Not applicable - - - - Liquid (GHS definition)
8 Self-reactive substances and mixtures Classification not possible - - - - Although it has S=O binding and P-O binding as a grouping relevant to autoreactive in a molecule, there is no data. So it cannot be classified.
9 Pyrophoric liquids Classification not possible - - - - No data available
10 Pyrophoric solids Not applicable - - - - Liquid (GHS definition)
11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to liquid substances are not available
12 Substances and mixtures which, in contact with water, emit flammable gases Not classified - - - - It is judged from water solubility, a water-octanol distribution coefficient, etc. being measured that it is stable in the water (ICSC (2001), Howard (1997), etc.).
13 Oxidizing liquids Classification not possible - - - - Classification not possible due to lack of data, though containing oxygen bonded to phosphorus and sulfur.
14 Oxidizing solids Not applicable - - - - Liquid (GHS definition)
15 Organic peroxides Not applicable - - - - Organic compounds containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - No data available

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 1 Danger H300: Fatal if swallowed P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P330: Rinse mouth.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 based on LD50=1.8mg/kg calculated from six data of rat LD50 values (ACGIH, (2001), PATTY (5th, 2001), PD No.44 (1980), PIMs (1998), and JMPR 239 (1972)).
1 Acute toxicity (Dermal) Category 1 Danger H310: Fatal in contact with skin P302+P350: IF ON SKIN: Gently wash with plenty of soap and water.
P262: Do not get in eyes, on skin, or on clothing.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P322: Specific treatment (see ... on this label).
P361: Remove/Take off immediately all contaminated clothing.
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was set as Category 1 based on LD50 = 5.2mg/kg calculated from eight data of rat LD50 value (ACGIH (2001), PATTY (5th, 2001), PD No.44 (1980), JMPR 239 (1972)).
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Liquid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Category 1 Danger H330: Fatal if inhaled P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P284: Wear respiratory protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P320: Specific treatment is urgent (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
The saturated vapor pressures concentrations pressure of this product is 0.0663ppm (0.00084mg/L), and it is thought that the inhalation study was done in mist. It was set as Category 1 based on LC50 = 0.0283mg/L calculated from eight data of rat LC50 value (ACGIH (2001), PATTY (5th, 2001), PD No.44 (1980), JMPR 239 (1972)).
2 Skin corrosion/irritation Category 3 - Warning H316: Causes mild skin irritation P332+P313: If skin irritation occurs: Get medical advice/attention. It was classified as Category 3 based on the statements that irritation was observed on humans with 5 consecutive days of administration (ACGIH (2001)) and that contact may indicate irritation to human skin (HSFS (2005)).
3 Serious eye damage/eye irritation Category 2B - Warning H320: Causes eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
It was set as Category 2B based on the statement (HSFS (2005)) that irritant to eye might be indicated by contact.
4 Respiratory sensitization Classification not possible - - - - No data available
4 Skin sensitization Classification not possible - - - - No data available
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories by the technical guidelines. Because there are no positive results in human multi-generation epidemiological tests, multi-generation mutagenicity tests and mutagenicity tests using germ cells and somatic cells, and there are records of negative results from dominant lethal tests in mice (ACGIH (2001), PD No.44 (1980), JMPR 239 (1972), JMPR 588 (1982)).
6 Carcinogenicity Not classified - - - - Based on being classified into A4 according to ACGIH (ACGIH (2001)), it carried out the outside of Category.
7 Reproductive toxicity Not classified - - - - Since there is no effect to reproductive potential of parent and development/growth of neonatal in rat, mouse, and rabbit, and there is no toxic effect to the third generation (ACGIH (2001), PATTY (5th, 2001), PD No.44 (1980), JMPR 588 (1982)), it was considered as on the outside of Categry.
8 Specific target organ toxicity - Single exposure Category 1 (nervous system) Danger H370: Causes damage to organs (nervous system) P307+P311: IF exposed: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P321: Specific treatment (see ... on this label).
P405: Store locked up.
P501: Dispose of contents/container to ...
There are descriptions that supression of cholinesterase is observed in the plasma and red corpuscle of humans and that symptoms such as cough, nausea, contracted pupils, muscular spasticity, an excess of saliva secretion, perspiration, suffocation, dizziness, ataxie, achalasia, vomiting and the loss of conciousness are caused (ACGIH (2001), PATTY (5th, 2001), RTECS (2004), ICSC (J) (1994), HSDB (2005)). There is a description that although the dosage is unknown, irreversible inhibition of cholinesterase activity is observed in animals, causing respiratory paralysis, hypoxia, and terminal spasm (ACGIH (2001)). It was set as Category 1(nerve systems) based on these information.
9 Specific target organ toxicity - Repeated exposure Category 1 (nervous system) Danger H372: Cause damage to organs through prolonged or repeated exposure (nervous system) P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ...
There is a statement of the inhibition of cholinesterase activity in serum, plasma, red blood cells and brain is seen and the accompanying symptoms (weight reduction, food consumption decreased, defective a health, and death) is also seen in rats and dogs in the exposure of guidance value within the limits of Cattegory 1(ACGIH (2001), PATTY (5th, 2001), PD No.44 (1980), JMPR 239 (1972), JMPR 588 (1982)) . The statement says that this material is a cholinesterase inhibitor to humans and the effects may be accumulated. It was classified to as Category 1 (nerve systems) based on these informations.
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
It was classified into Category 1 from 96-hour TLm=0.12mg/L of fishes (Bluegill) (PDS, 1980).
11 Hazardous to the aquatic environment (Long-term) Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ...
Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=2.23(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model SDS by MHLW

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