GHS Classification Result

Chemical Name:Trichloroacetic acid
CAS:76-03-9

Result:
ID: 604
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual (10 Feb, 2006)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases (including chemically unstable gases) Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Not classified - - - - Non-combustible (ICSC (J), 1998; etc.)
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Not classified - - - - Non-combustible (ICSC (J), 1998; etc.)
11 Self-heating substances and mixtures Not classified - - - - Non-combustible (ICSC(J), 1998; etc.)
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not classified - - - - UNRTDG Class: 8
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available. Corrosive to aluminum or etc. according to some reports.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity (Oral) Category 5 - Warning H303: May be harmful if swallowed P312: Call a POISON CENTER or doctor/physician if you feel unwell. SPECIES: Rat ENDPOINT: LD50 VALUE: 3320 mg/kg REFERENCE SOURCE: ACGIH (7th, 2001)
1 Acute toxicity (Dermal) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)
1 Acute toxicity (Inhalation: Vapours) Classification not possible - - - - No data available
1 Acute toxicity (Inhalation: Dusts and mists) Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 1A-1C Danger H314: Causes severe skin burns and eye damage P301+P330+P331: IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353: IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
P321: Specific treatment (see ... on this label).
P363: Wash contaminated clothing before reuse.
P405: Store locked up.
P501: Dispose of contents/container to ...
Based on the description that although the strength varies depending on the concentration and exposure time, and it is corrosive to skin (ACGIH (7th, 2001)), it was classified as Category 1A-1C.
3 Serious eye damage/eye irritation Category 1 Danger H318: Causes serious eye damage P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P310: Immediately call a POISON CENTER or doctor/physician.
From description that severe injury was admitted by the test applied to the ocular of the rabbit on ACGIH (7th, 2001), and change which corresponded to the acceptance criteria of critical ocular lesional (irreversible effects) in the ocular of rabbit which was applied the 30% solution shown in ECETOC TR 48 (1992) was admitted, it was set as Category 1.
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although the possibility of putting it outside of the Category was considered from the description that skin sensitization was not found in Mouse-Ear-Swelling test of IUCLID (2000) and BUA 167 (1995), and maximization test using guinea pigs, it was decided that it could not be classified because there was no data to deny its harmful rffects clearly in Priority 1.
5 Germ cell mutagenicity Category 2 Warning H341: Suspected of causing genetic defects P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Although there are positive (IARC 63, 1999, IRIS, 2005) and negative (IARC 63, 1995) results from micronucleus tests using mouse erythrocytes, which are in vivo mutagenicity tests using somatic cells, and positive results from the chromosome aberration test using mouse bone-marrow cells (IARC 63, 1995, IRIS, 2005) (the original text is the same). But there are no positive results from in vivo genotoxicity tests in germ cells. So the substance was classified as Category 2.
6 Carcinogenicity Category 2 Warning H351: Suspected of causing cancer P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
It was classified into the group 3 (IARC 63, 1995) according to IARC and was classified into C (IRIS, 2005) according to EPA1986. But it was classified into A3 according to ACGIH (7th, 2001), it was set as 2.
7 Reproductive toxicity Category 2 Warning H361: Suspected of damaging fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ...
Since there is the description of obvious reproductive toxicity in the dose causing general toxicity to parent animals in oral administration test with pregnancy 6-15 days using rat (ACGIH (7th, 2001) and IARC 63 (1995)), it is classified into the Category 2.
8 Specific target organ toxicity - Single exposure Category 2 (respiratory system), Category 3 (narcotic effects) Warning H371: May cause damage to organs (respiratory system)
H336: May cause drowsiness or dizziness (narcotic effects)
P309+P311: IF exposed or if you feel unwell: Call a POISON CENTER or doctor/physician.
P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P405: Store locked up.
P501: Dispose of contents/container to ...
P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
Based on the description that lung edemas may be caused, when the vapor is inhaled (ICSC (J) (1998), HSFS (2004), and SITTIG (4th, 2002)), it was set as Category 2 (respiratory tracts). Moreover, it was set as Category 3 (anesthetic actions) based on the description that an anesthetic action was identified by oral administration to the rat and mouse (ACGIH (7th, 2001)).
9 Specific target organ toxicity - Repeated exposure Not classified - - - - It was carried out of the Category because significant toxicity is not ackowledged by over dose of the guidance value range of Category 2 in an administration test in drinking water for 90 days using the rat of ACGIH (7th, 2001) and IARC 63 (1995)
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment (Acute) Not classified - - - - It carried out the outside of Category from 48-hour EC50=2000mg/L of Crustacea (Daphnia magna) (SIDS, 2000).
11 Hazardous to the aquatic environment (Long-term) Not classified - - - - Since not water-insoluble (aqueous solubility =44000 mg/L (PHYSPROP Database, 2005)) and acute toxicity is low.


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference:
Reference Manual

Definitions / Abbreviations

Model Label by MHLW

MHLW Website (in Japanese Only)

Model SDS by MHLW

MHLW Website (in Japanese Only)


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