GHS Classification Result

Chemical Name：2,4,5-T
CAS：93-76-5

Result：
ID: 605
Classifier: Inter-ministerial Committee on GHS
Year Classified: FY2006
Reference Manual: GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecules.
2 Flammable gases （including chemically unstable gases） Not applicable - - - - Solid (GHS definition)
3 Aerosols Not applicable - - - - Not aerosol products
4 Oxidizing gases Not applicable - - - - Solid (GHS definition)
5 Gases under pressure Not applicable - - - - Solid (GHS definition)
6 Flammable liquids Not applicable - - - - Solid (GHS definition)
7 Flammable solids Classification not possible - - - - Although there is information that it is inflammable (however, flame proofs), there is no data with defined test method.
8 Self-reactive substances and mixtures Not applicable - - - - There are no chemical groups associated with explosive or self-reactive properties present in the molecule.
9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)
10 Pyrophoric solids Classification not possible - - - - No data available
11 Self-heating substances and mixtures Classification not possible - - - - Although there is information of flammable (however, flame retardant), no data based on a set test method.
12 Substances and mixtures which, in contact with water, emit flammable gases Not applicable - - - - The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)
14 Oxidizing solids Not applicable - - - - Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15 Organic peroxides Not applicable - - - - Containing no -0-0- structure
16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
1 Acute toxicity （Oral） Category 4 Warning H302: Harmful if swallowed P301+P312: IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P330: Rinse mouth.
P501: Dispose of contents/container to ... 		Based on rat LD50 value: 500 to 750 mg/kg (DFGOT vol.11, 1998), the lowest value was adopted and it was set as Category 4.
1 Acute toxicity （Dermal） Category 4 Warning H312: Harmful in contact with skin P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P322: Specific treatment （see ... on this label）.
P363: Wash contaminated clothing before reuse.
P501: Dispose of contents/container to ... 		Based on rat LD50 value: 1535mg/kg (RTECS, 2005) and >5000mg/kg (HSDB, 2005), the lowest value was adopted and it was set as Category 4.
1 Acute toxicity （Inhalation: Gases） Not applicable - - - - Solid (GHS definition)
1 Acute toxicity （Inhalation: Vapours） Classification not possible - - - - No data available
1 Acute toxicity （Inhalation: Dusts and mists） Classification not possible - - - - No data available
2 Skin corrosion/irritation Category 2 Warning H315: Causes skin irritation P302+P352: IF ON SKIN: Wash with plenty of soap and water.
P332+P313: If skin irritation occurs: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection.
P321: Specific treatment （see ... on this label）.
P362: Take off contaminated clothing and wash before reuse. 		It was classified as Category 2 from description that the skin is stimulated (ICSC (J) (1995), HSDB (2005), HSFS (2001), and SITTIG (4th, 2002)).
3 Serious eye damage/eye irritation Category 2A Warning H319: Causes serious eye irritation P305+P351+P338: IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P337+P313: If eye irritation persists: Get medical advice/attention.
P264: Wash ... thoroughly after handling.
P280: Wear protective gloves/protective clothing/eye protection/face protection. 		From description that the eye of the rat is stimulated strongly (DFGOT (vol.11, 1998) , and from description that the eye is stimulated (ICSC (J) (1995), HSDB (2005), HSFS (2001), and SITTIG (4th, 2002)), it was set as Category 2A .
4 Respiratory sensitization Classification not possible - - - - No data
4 Skin sensitization Classification not possible - - - - Although a possibility of putting it outside of the Category is considered from the description that any allergic nature was not identified in the guinea pigs of DFGOT (vol.11, 1998), it was judged that the test method was not clear enough and data was not sufficient enough to put it outside of the Category.
5 Germ cell mutagenicity Not classified - - - - The substance was regarded as outside the categories. Because of negative results from dominant lethal tests in rats and mice (DFGOT vol.11, 1998, IARC 41, 1986), chromosome aberration tests using hamster spermatogenic cells (DFGOT vol.11, 1998, IARC Suppl. 7 1986), and chromosome aberration tests and micronucleus tests using mouse bone-marrow cells (DFGOT vol.11, 1998).
6 Carcinogenicity Not classified - - - - Chlorophenoxy herbicides is classified into 2B according to IARC (41, 1987). But 2,4,5-T was classified into A4 according to ACGIH (7th, 2001). Therefore, it carried out the outside of category based on the segment of ACGIH which is the latest evaluation.
7 Reproductive toxicity Category 1B Danger H360: May damage fertility or the unborn child P308+P313: IF exposed or concerned: Get medical advice/attention.
P201: Obtain special instructions before use.
P202: Do not handle until all safety precautions have been read and understood.
P281: Use personal protective equipment as required.
P405: Store locked up.
P501: Dispose of contents/container to ... 		There are descriptions that the result which indicates teratogenicity or increase of abortions is not obtained in an epidemiological study (ACGIH (7th, 2001), DFGOT (vol.11, 1998), and IARC (45, 1998)). However, in the study using mouse and rat, there is a description that specific reproductive toxicity was observed with the dose which general toxicity is not observed in parental animals (DFGOT (vol.11, 1998)). Therefore, it was classified into Category 1B.
8 Specific target organ toxicity - Single exposure Category 3 （Respiratory tract irritation） Warning H335: May cause respiratory irritation (respiratory tract irritation) P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P403+P233: Store in a well-ventilated place. Keep container tightly closed.
P261: Avoid breathing dust/fume/gas/mist/vapours/spray.
P271: Use only outdoors or in a well-ventilated area.
P312: Call a POISON CENTER or doctor/physician if you feel unwell.
P405: Store locked up.
P501: Dispose of contents/container to ... 		It was set as Category 3 (respiratory tracts irritation) based on the description that the respiratory tracts are irritated ( ICSC (J) (1995), HSDB (2005), HSFS (2001), and SITTIG (4th, 2002)).
9 Specific target organ toxicity - Repeated exposure Category 1 (skin), Category 2 (kidney, immune system) Danger
Warning 		H372: Cause damage to organs through prolonged or repeated exposure (skin)
H373: May cause damage to organs through prolonged or repeated exposure (kidney, immune system) 		P260: Do not breathe dust/fume/gas/mist/vapours/spray.
P264: Wash ... thoroughly after handling.
P270: Do not eat, drink or smoke when using this product.
P314: Get medical advice/attention if you feel unwell.
P501: Dispose of contents/container to ... 		It was classified to Category 1 as the skin is considered target organ because of the description that chloracne is found in the manufacturing workers of DFGOT (vol.11, 1998). Moreover, it was classified to Category 2 as kidney and immune systems are considered target organ because of the description that the renal effects and decrease of white corpuscles were acknowledged in guidance value Category 2 by the oral study using the rats of DFGOT (vol.11, 1998), and because of the description that lymphopenia was acknowledged in guidance value Category 2 by the oral study using the dogs of ACGIH (7th, 2001).
10 Aspiration hazard Classification not possible - - - - No data available

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
11 Hazardous to the aquatic environment （Acute） Category 1 Warning H400: Very toxic to aquatic life P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		It was classified into Category 1 from 96-hour LC50=0.98mg/L of fishes (Rainbow trout) (HSDB, 2004) .
11 Hazardous to the aquatic environment （Long-term） Category 1 Warning H410: Very toxic to aquatic life with long lasting effects P273: Avoid release to the environment.
P391: Collect spillage.
P501: Dispose of contents/container to ... 		Classified into Category 1, since acute toxicity was Category 1, supposed not rapidly degrading (BIOWIN), though supposed less bioaccumulative (log Kow=3.31(PHYSPROP Database, 2005)).


NOTE:
* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：
Reference Manual
Definitions / Abbreviations
Model SDS by MHLW

 MHLW Website （in Japanese Only）

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