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GHS Classification Result

Chemical Name：dieldrin
CAS：60-57-1

Result：


ID:	610
Classifier:	Inter-ministerial Committee on GHS
Year Classified:	FY2006
Reference Manual:	GHS Classification Manual （10 Feb, 2006）

PHYSICAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Explosives	Not applicable	-	-	-	-	There are no chemical groups associated with explosive properties present in the molecules.
2	Flammable gases （including chemically unstable gases）	Not applicable	-	-	-	-	Solid (GHS definition)
3	Aerosols	Not applicable	-	-	-	-	Not aerosol products
4	Oxidizing gases	Not applicable	-	-	-	-	Solid (GHS definition)
5	Gases under pressure	Not applicable	-	-	-	-	Solid (GHS definition)
6	Flammable liquids	Not applicable	-	-	-	-	Solid (GHS definition)
7	Flammable solids	Not classified	-	-	-	-	Non-combustible (ICSC (J), 1998; etc.)
8	Self-reactive substances and mixtures	Classification not possible	-	-	-	-	No data available
9	Pyrophoric liquids	Not applicable	-	-	-	-	Solid (GHS definition)
10	Pyrophoric solids	Not classified	-	-	-	-	Non-combustible (ICSC (J), 1998; etc.)
11	Self-heating substances and mixtures	Not classified	-	-	-	-	Non-combustible (ICSC(J), 1998; etc.)
12	Substances and mixtures which, in contact with water, emit flammable gases	Not applicable	-	-	-	-	The chemical structure of the substance does not contain metals or metaloids(B, Si, P, Ge, As, Se, Sn, Sb, Te, Bi, Po, At).
13	Oxidizing liquids	Not applicable	-	-	-	-	Solid (GHS definition)
14	Oxidizing solids	Not applicable	-	-	-	-	Organic compounds containing oxygen and chlorine (but not fluorine) and these elements are chemically bonded only to carbon and hydrogen (but not to other elements).
15	Organic peroxides	Not applicable	-	-	-	-	Containing no -0-0- structure
16	Corrosive to metals	Classification not possible	-	-	-	-	Test methods applicable to solid substances are not available. Slightly corrosive to metals(HSDB, Access on Dec. 2005)

HEALTH HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
1	Acute toxicity （Oral）	Category 1		Danger	H300: Fatal if swallowed	P301+P310: IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P330: Rinse mouth. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 1 based on the description (PATTY 4th.1994, Priority 1) that LD50 in humans is 5mg/kg.
1	Acute toxicity （Dermal）	Category 1		Danger	H310: Fatal in contact with skin	P302+P350: IF ON SKIN: Gently wash with plenty of soap and water. P262: Do not get in eyes, on skin, or on clothing. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P280: Wear protective gloves/protective clothing/eye protection/face protection. P310: Immediately call a POISON CENTER or doctor/physician. P322: Specific treatment （see ... on this label）. P361: Remove/Take off immediately all contaminated clothing. P363: Wash contaminated clothing before reuse. P405: Store locked up. P501: Dispose of contents/container to ...	It was set as Category 1 based on the value (50mg/kg) calculated from rat LD50 (60, 50, and 120mg/kg (PD 17 (1975), EHC 91 (1989), ACGIH (7th, 2001), and PIM 575 (1975)).
1	Acute toxicity （Inhalation: Gases）	Not applicable	-	-	-	-	Solid (GHS definition)
1	Acute toxicity （Inhalation: Vapours）	Classification not possible	-	-	-	-	No data available
1	Acute toxicity （Inhalation: Dusts and mists）	Category 1		Danger	H330: Fatal if inhaled	P304+P340: IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing. P403+P233: Store in a well-ventilated place. Keep container tightly closed. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P271: Use only outdoors or in a well-ventilated area. P284: Wear respiratory protection. P310: Immediately call a POISON CENTER or doctor/physician. P320: Specific treatment is urgent （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	Category 1 because of "SPECIES: Rat; ENDPOINT: LC50; VALUE: 0.013mg/L"(RTECS, 2005)
2	Skin corrosion/irritation	Classification not possible	-	-	-	-	Classification not possible due to lack of data
3	Serious eye damage/eye irritation	Classification not possible	-	-	-	-	No data available
4	Respiratory sensitization	Classification not possible	-	-	-	-	No data available
4	Skin sensitization	Classification not possible	-	-	-	-	No data available
5	Germ cell mutagenicity	Not classified	-	-	-	-	The substance was regarded as outside the categories. Based on the report that results from dominant lethal tests in mice, chromosome aberration tests in Chinese hamster bone-marrow cells, reciprocal translocation tests in mice, chromosome aberration tests in rats and mice and micronucleus tests in mice (JMPR 1977, EHC 91 1989) are all negative.
6	Carcinogenicity	Not classified	-	-	-	-	It was classified into group 3 according to IARC (1987), into A4 according to ACGIH (proposal year 1995, 7th, 2001), into B2 according to EPA (the 1986 evaluation, (IRIS, 2005)), and into category 3 according to EU (proposal year unknown, EU ANNEX I and 2005). And evaluation of IARC was respected and it carried out the outside of Category based on ACGIH (1995) which is latest assessment.
7	Reproductive toxicity	Category 1B		Danger	H360: May damage fertility or the unborn child	P308+P313: IF exposed or concerned: Get medical advice/attention. P201: Obtain special instructions before use. P202: Do not handle until all safety precautions have been read and understood. P281: Use personal protective equipment as required. P405: Store locked up. P501: Dispose of contents/container to ...	Since there is the description that there is the lesion in neonatal's brain at the dose cause the toxicity in the maternal animals of rat (JMPR 1979, EHC 91, 1989), and it is indicated in the lack of irreversible and congenital survival ability occur in the neonatal which was born from the maternal animals which is given the administration of test material in mouse, and additionally, it was indicated that this lack of survival ability and the decrease of nursing ability of the maternal animal cause the increase child mortality (EHC 91, 1989), it is classified into the Category 1B.
8	Specific target organ toxicity - Single exposure	Category 1 (central nervous system)		Danger	H370: Causes damage to organs (central nervous system)	P307+P311: IF exposed: Call a POISON CENTER or doctor/physician. P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P321: Specific treatment （see ... on this label）. P405: Store locked up. P501: Dispose of contents/container to ...	In humans, central-nerve neurosis such as spasm is identified with 5mg/kg set to LD50 (PATTY, 4th.1994), and it had an influence with the mouse on its central nerve systems enhancing the effects of seizure inducers, etc. (JMPR 1967). So it was set as Category 1(central nervous systems).
9	Specific target organ toxicity - Repeated exposure	Category 1 (central nervous system, liver)		Danger	H372: Cause damage to organs through prolonged or repeated exposure (central nervous system, liver)	P260: Do not breathe dust/fume/gas/mist/vapours/spray. P264: Wash ... thoroughly after handling. P270: Do not eat, drink or smoke when using this product. P314: Get medical advice/attention if you feel unwell. P501: Dispose of contents/container to ...	It was classified to as Category 1 (central nervous systems, liver), since the workers in Dieldrin manufacture got poisoning, and occured the central nervous system symptoms (JMPR/1970, 1977, EHC 91, 1989, ACGIH 4th. 1994), and the central nervous system symptomsin dogs and rats (JMPR 1970, and EHC 91, 1989 and MOE Risk Assessment/-- the 1st volume, 2002) , and rodent ulcer of liver in rats by a chlorinated hydrocarbonic insecticide were both acknowledged by the dosage of guidance value within the limits of Category 1.
10	Aspiration hazard	Classification not possible	-	-	-	-	No data available

ENVIRONMENTAL HAZARDS

Hazard class		Classification	Symbol	Signal word	Hazard statement	Precautionary statement	Rationale for the classification
11	Hazardous to the aquatic environment （Acute）	Category 1		Warning	H400: Very toxic to aquatic life	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	It was classified into Category 1 from 96-hour LC50=0.4microg/L of Crustacea (Brown shrimp) (EHC91, 1989).
11	Hazardous to the aquatic environment （Long-term）	Category 1		Warning	H410: Very toxic to aquatic life with long lasting effects	P273: Avoid release to the environment. P391: Collect spillage. P501: Dispose of contents/container to ...	Classified into Category 1, since acute toxicity is Category 1,not rapidly degrading (BOD: 0% (existing chemical substances safety inspections data)), and bioaccumulative (BCF=14500 (existing chemical substances safety inspections data)).

NOTE:

* Classification was conducted by relevant Japanese Ministries in accordance with GHS Classification Guidance for the Japanese Government, and is intended to provide a reference for preparing GHS labelling and SDS for users.
* This is a provisional English translation of classification results and is subject to revision without notice.
* The responsibility for any resulting GHS labelling and SDS referenced from this site is with users.

Reference：

Reference Manual
Definitions / Abbreviations
Model SDS by MHLW	MHLW Website （in Japanese Only）